Type 2 Diabetes Associated with Alzheimer's Disease Neurodegeneration
Lower bilateral frontal and parietal cortical thickness also noted in individuals with type 2 diabetes.
HealthDay News -- Individuals with type 2 diabetes may be more prone to developing the neuropathology associated with Alzheimer's disease, according to a study published in Neurology.
Velandai Srikanth, MBBS, PhD, a geriatrician at Monash University in Melbourne, Australia, and colleagues based their findings on 124 older adults with type 2 diabetes and 692 without the disease. Some had Alzheimer's, others had mild cognitive impairment, and others had normal cognition.
All of the study participants underwent magnetic resonance imaging, and about half had samples taken of their cerebrospinal fluid to measure levels of β-amyloid and tau proteins.
Overall, individuals with diabetes had lower bilateral frontal and parietal cortical thickness. Those with type 2 diabetes also had higher levels of tau protein in their cerebrospinal fluid.
"Type 2 diabetes may promote neurodegeneration independent of Alzheimer's disease dementia diagnosis, and its effect may be driven by tau phosphorylation," the authors write. "The mechanisms through which type 2 diabetes may promote tau phosphorylation deserve further study."