Type 2 Diabetes

Oxyntomodulin Augments Glucose Homeostasis

Oxyntomodulin Augments Glucose Homeostasis

In obese subjects with and without type 2 diabetes, oxyntomodulin significantly augments glucose-dependent insulin secretion.

Increased Risk for Mortality in People With Diabetes, CHD Taking Beta-Blockers

Increased Risk for Mortality in People With Diabetes, CHD Taking Beta-Blockers

By

Further studies are needed to assess whether beta-blockers are effective in reducing mortality and coronary events in patients with diabetes receiving optimal medical treatment.

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

By

In patients with insulin-treated diabetes and sepsis, increased highest glucose levels and glycemic variability have a significant illness severity-adjusted association with decreasing in-hospital mortality.

Clinicians May Be Overtreating Older Patients With Diabetes

Clinicians May Be Overtreating Older Patients With Diabetes

By

Future research should further investigate the process and influences on clinician decision-making regarding individualizing glucose targets for high-risk geriatric patients, including the influence of training and practice environment.

Sacubitril/Valsartan May Help Preserve Kidney Function in Patients With HFrEF

Sacubitril/Valsartan May Help Preserve Kidney Function in Patients With HFrEF

By

Compared with the enalapril-treated group, those treated with sacubitril/valsartan were found to have significantly slower kidney decline.

No association of overweight childhood and adult type 2 diabetes risk after weight loss

Compared to men who were never overweight, those overweight at age 7 who returned to a normal body mass index by age 13 had no increased risk for developing type 2 diabetes.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in T1D vs T2D

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in T1D vs T2D

By

The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

Pharmacists Can Help With Diabetes Management via Telemedicine

Pharmacists Can Help With Diabetes Management via Telemedicine

Telemedicine could provide real-time feedback loop and allow pharmacists to help patients self-manage.

Soluble Klotho Levels Predictive of Kidney Failure in Type 2 Diabetes

Soluble Klotho Levels Predictive of Kidney Failure in Type 2 Diabetes

By

In patients with type 2 diabetes and with relatively preserved estimated glomerular filtration rate, reduced levels of soluble Klotho predict renal function decline independent of traditional risk markers.

Rising Incidence of Diabetes in Adults With HIV on Antiretroviral Therapy

Rising Incidence of Diabetes in Adults With HIV on Antiretroviral Therapy

By

More research is needed to better capture the interplay between prediabetes/diabetes and antiretroviral therapy in people with HIV.

Canagliflozin May Improve Renal Outcomes in Patients With Type 2 Diabetes

Canagliflozin May Improve Renal Outcomes in Patients With Type 2 Diabetes

By

The renal protective benefit was seen in patients with both reduced (eGFR <60mL/min/1.73m2) and preserved (eGFR ≥60mL/min/1.73m2) renal function.

Eating Pecans May Cut Risk for Cardiovascular Disease, Diabetes

Eating Pecans May Cut Risk for Cardiovascular Disease, Diabetes

Changes in serum insulin and homeostatic model assessment of insulin resistance and beta cell function were significantly greater compared to the control diet

Consensus Report Defines Treatment Success in β-Cell Replacement Therapy

Consensus Report Defines Treatment Success in β-Cell Replacement Therapy

By

IPITA and EPITA held a workshop to develop consensus for a joint statement on the definition of function and failure of current and future forms of β-cell replacement therapy.

Lactation Lowers Risk for T2D After Gestational Diabetes

Lactation Lowers Risk for T2D After Gestational Diabetes

For women with previous gestational diabetes, lactation is associated with reduced risk of type 2 diabetes, although there is no benefit for long-term lactation.

Skin Nodule Manipulation Leads to Adverse Drug Reactions in a T2D Patient

Skin Nodule Manipulation Leads to Adverse Drug Reactions in a T2D Patient

By

The patient, a 50-year old male, presented to the emergency department with palpitations and complaints of nausea, retching and diarrhea which he said started after he squeezed a nodule on his thigh.

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

Diabetes Does Not Alter Anti-Osteoporotic Treatment Response

By

Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.

Noninvasive CAD Screening May Reduce Cardiac Events in Individuals With Asymptomatic Diabetes

Noninvasive CAD Screening May Reduce Cardiac Events in Individuals With Asymptomatic Diabetes

By

Compared with standard care, noninvasive coronary artery disease screening reduced cardiac events by 27% in individuals with asymptomatic diabetes. Results justify larger, appropriately powered trials to potentially revisit current recommendations.

Grilled Meat, Chicken Increases Risk for Type 2 Diabetes in US Adults

Grilled Meat, Chicken Increases Risk for Type 2 Diabetes in US Adults

Open-flame and/or high-temperature cooking methods (such as grilling/barbecuing, broiling, or roasting) to prepare chicken and red meat are associated with an increased risk of type 2 diabetes.

Risk for Congenital Anomaly With Exposure to Insulin Analogues in the First Trimester

Risk for Congenital Anomaly With Exposure to Insulin Analogues in the First Trimester

By

Results suggest that first trimester use of insulin analogues does not increase the risk for a congenital anomaly in women with diabetes compared with the use of human insulin.

Successful Hepatitis C Treatment May Reduce Risk for Developing T2D

Successful Hepatitis C Treatment May Reduce Risk for Developing T2D

By

Among a large US cohort of patients treated for HCV, patients who achieved sustained virologic response demonstrated a substantially lower risk for development of type 2 diabetes than patients with treatment failure.

Safety, Efficacy of Degludec/Liraglutide Fixed-Ratio Combination in Uncontrolled T2D

Safety, Efficacy of Degludec/Liraglutide Fixed-Ratio Combination in Uncontrolled T2D

By

IDegLira provides an efficacious intensification option with noninferior glycemic control vs basal-bolus in patients with type 2 diabetes receiving 20 to 50 units of basal insulin with no renal impairment and HbA1c levels of 7% to 10%.

Bydureon Single Dose Trays to Be Discontinued

Bydureon Single Dose Trays to Be Discontinued

By

The Food and Drug Administration (FDA) has issued a discontinuation notice for Bydureon (exenatide extended-release; AstraZeneca) for injectable suspension Single Dose Trays.

Risk Factors for Developing Diabetic Polyneuropathy in Type 2 Diabetes

Risk Factors for Developing Diabetic Polyneuropathy in Type 2 Diabetes

By

Study provides stronger epidemiological evidence for obesity as a risk factor for diabetic polyneuropathy.

Bydureon Approved for Use With Basal Insulin for Uncontrolled T2D

Bydureon Approved for Use With Basal Insulin for Uncontrolled T2D

By

The DURATION-7 study examined the effect of Bydureon or placebo as add-on therapy to insulin glargine, with or without metformin, in adults with T2D.

Chronic Kidney Disease May Be Common in Veterans Prior to Diabetes Diagnosis

Chronic Kidney Disease May Be Common in Veterans Prior to Diabetes Diagnosis

By

The study adds insight to the extent of both racial and regional variations in the prevalence of chronic kidney disease while calling attention to the magnitude of this disease in patients prior to being diagnosed with diabetes.

Cardiovascular Outcomes of SGLT-2i vs Other Glucose-Lowering Drugs in T2D

Cardiovascular Outcomes of SGLT-2i vs Other Glucose-Lowering Drugs in T2D

By

A recent study evaluated the effects of SGLT-2i and other glucose-lowering drugs on cardiovascular event outcomes in patients with type 2 diabetes from 6 countries in 3 world regions.

Independent Risk Pathways Shown for Diabetes and Obesity in Adults With Serious Mental Illness

Independent Risk Pathways Shown for Diabetes and Obesity in Adults With Serious Mental Illness

By

Given the high risk for metabolic disorder and type 2 diabetes, clinicians should select psychotropic medications carefully and monitor metabolic conditions regularly in their patients with serious mental illness.

Canakinumab Does Not Appear to Prevent Diabetes Onset

Canakinumab Does Not Appear to Prevent Diabetes Onset

By

The new analysis focuses on the remaining 4960 patients, who had prediabetes at the start of the trial.

Food Insecurity Tied to Poor Glycemic Control in Diabetes

Food Insecurity Tied to Poor Glycemic Control in Diabetes

Food insecurity screening and interventions may help improve glycemic control for vulnerable patients.

Low-Grade Inflammatory Markers May Help Differentiate Diabetes Diagnoses in Adults

Low-Grade Inflammatory Markers May Help Differentiate Diabetes Diagnoses in Adults

By

Study provided evidence of significant differences in median serum concentrations of circulating adipose-related inflammatory biomarkers across the main diabetes types.

Sign Up for Free e-Newsletters

CME Focus