Reduced Levels of Some Stem Cells Predict CV Events in Type 2 Diabetes

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Reduced levels of certain stem cells may predict adverse cardiovascular outcomes in type 2 diabetes.
Reduced levels of certain stem cells may predict adverse cardiovascular outcomes in type 2 diabetes.

HealthDay News -- Reduced baseline levels of circulating CD34+ stem cells predict adverse cardiovascular (CV) outcomes for patients with type 2 diabetes, according to a study published in Diabetes Care.

Gian Paolo Fadini, MD, PhD, from the University of Padova in Italy, and colleagues monitored a cohort of 187 patients with type 2 diabetes for a median of 6.1 years. Six stem/progenitor cell phenotypes were measured in peripheral blood at baseline, based on expression of CD34, CD133, and KDR.

The researchers found that the primary outcome of time to a first CV event plus hospitalization for CV causes occurred in 48 patients (4.5/100 patient-years). Significantly lower CD34+ and CD34+CD133+ cells were seen in patients with vs those without incident CVevents. The rates of CV events were higher in patients with below median levels of CD34+ and CD34+CD133+. Reduced CD34+ and CD34+CD133+ cell count independently predicted future events in hazard regression analyses (hazard ratios: 2.21 and 2.98, respectively). 

C statistics, continuous net reclassification improvement, and/or integrated discrimination index were improved with addition of the CD34+ cell count to the reference model or the UK Prospective Diabetes Study risk engine.

"In patients with type 2 diabetes, a reduced baseline level of circulating CD34+ stem cells predicts adverse cardiovascular outcomes up to six years later and improves risk stratification," the researchers wrote.

Reference

  1. Fadini GP, Rigato M, Cappellari R, Bonora BM, Avogaro A. Long-term prediction of cardiovascular outcomes by circulating CD34+ and CD34+CD133+ stem cells in patients with type 2 diabetes. Diabetes Care. 2016 Nov 4. doi:10.2337/dc16-1755 [Epub ahead of print].
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