Intensive Blood Pressure Lowering Reduces CV Events Similarly in Patients With/Without T2D
Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes.
HealthDay News — Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus, according to a study published online in Diabetes Care.
Tom F. Brouwer, MD, from the University of Amsterdam, and colleagues assessed the effect of both type 2 diabetes and baseline cardiovascular disease risk on the treatment effect of intensive blood pressure lowering based on data and pooled analysis from 2 randomized trials (ACCORD-BP [Action to Control Cardiovascular Risk in Diabetes Blood Pressure]and SPRINT [Systolic Blood Pressure Intervention Trial] studies; total of 14,094 patients).
The researchers found that the mean baseline systolic blood pressure was 139.5 mm Hg for the cohort and just over one-third (33.6%) had type 2 diabetes. The hazard ratio for the primary composite end point of unstable angina, myocardial infarction, acute heart failure, stroke, and cardiovascular death was 0.82 (P = .0017).
There was a nonsignificant interaction between intensive blood pressure lowering and type 2 diabetes (P = .13). While the 10-year cardiovascular risk was higher in patients with type 2 diabetes, there was no interaction between the risk and treatment effect (P = .84).
"Intensive blood pressure lowering may have a similar favorable effect and appears to decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus," the authors write.
Brouwer TF, Vehmeijer JT, Kalkman DN. Intensive blood pressure lowering in patients with and patients without type 2 diabetes: a pooled analysis from two randomized trials [published online December 6, 2017]. Diabetes Care. doi: 10.2337/dc17-1722