Type 2 Diabetes Archive
The ADA published its 2019 Standards of Medical Care in Diabetes, an evidence-based document intended to provide clinicians, patients, and other stakeholders in the diabetes treatment landscape with up-to-date recommendations.
For this study, the authors identified randomized controlled trials (RCTs) that compared SGLT2 inhibitors with placebo, no treatment, or another antidiabetic agent and reported on UTI outcome.
Metabolic syndrome and psoriatic arthritis were highly prevalent comorbidities in patients with plaque psoriasis.
Type 2 diabetes is associated with declines in verbal memory and fluency among older community-dwelling adults.
Patients with stable type 2 diabetes may be unnecessarily self-monitoring blood glucose levels despite this practice being recognized as a low-value service.
A significant reduction in major cardiac events among elderly patients was seen in the liraglutide treatment group.
A hip fracture risk tool for patients with type 2 diabetes performed well in predicting incident hip fractures using readily available variables.
Postpartum women with an elevated BMI score and a history of hypertensive disorders during pregnancy have an increased risk of developing type 2 diabetes.
Type 2 diabetes (T2D) is associated with an increased risk for colorectal cancer (CRC), with the association significant for men only.
Normalized HbA1c levels facilitated improvement in neuropathy and nephropathy in type 2 diabetes of a short duration.
Compared with GLP-1 receptor agonists, the use of SGLT2 inhibitors is associated with an increased risk for diabetic ketoacidosis and lower limb amputation.
Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease (CVD), and mortality in the general population.
High blood sugar levels may put patients with bipolar disorder at risk of not responding to lithium and other mood stabilizer treatments.
Female nurses who frequently work rotating night shifts and adhere to an unhealthy lifestyle are at significantly greater risk of developing type 2 diabetes.
About one in four patients report cost-related insulin underuse, which is associated with poor glycemic control.
The rising cost of insulin has made it increasingly difficult for patients with diabetes to receive affordable, life-saving medication, especially patients from low-income backgrounds, patients with high deductibles, and uninsured patients.
Among individuals at a high risk for cardiovascular disease, a panel of short- and long-chain acylcarnitines was significantly associated with the incidence of type 2 diabetes.
Reducing triglyceride levels in patients with type 2 diabetes may help them attain more optimal glycemic control.
From 2018 to 2030, the insulin required to treat type 2 diabetes is expected to increase more than 20 percent.
The addition of ezetimibe to simvastatin reduced ischemic risk compared with placebo, with consistent relative risk reductions in patients with and without polyvascular disease.
The American College of Cardiology published an expert consensus statement regarding decision considerations for novel cardiovascular risk reduction therapies in patients with type 2 diabetes and atherosclerotic cardiovascular disease.
In patients with T2D and acute coronary syndrome, treatment with the short-acting glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide reduced urinary albumin-to-creatinine ratio.
With obesity reaching epidemic proportions, and its known association with many metabolic disorders such as type 2 diabetes, dyslipidemia, hypertension, and atherosclerosis, it is worthwhile to look at nutritional approaches to managing these chronic conditions.
Linagliptin added to usual care compared with placebo added to usual care resulted in a noninferior risk for a composite cardiovascular or renal outcome over a median 2.2 years.
The 3 main types of diabetes during pregnancy were associated with offspring ADHD risk in a hierarchical order.
High circulating total prolactin concentrations may be linked with a lower risk for type 2 diabetes in women.
Dapagliflozin was not associated with either a higher or lower rate of MACE compared with placebo in patients with type 2 diabetes who had or were at risk for atherosclerotic cardiovascular disease.
Direct-Acting Antiviral Therapy Reduced Risk for Incident T2D in Patients With Hepatitis C Infection
The study compared US administrative claims data of HCV patients with ≥12 weeks of dispensed DAA therapy (N = 17,848) to untreated HCV patients with follow-up data (N = 108,350).
The American Diabetes Association issued a position statement outlining the recognition, management, and prevention of T2D in the pediatric population.
Patients with diabetes and depressive symptoms who received community-based peer support for diabetes management reported less frequent acute care visits and hospitalizations than patients with diabetes without depressive symptoms.
Postprandial hypoglycemia may occur after Roux-en-Y gastric bypass in patients with type 2 diabetes, independent from diabetes remission.
Approximately 50% of deaths in people with type 2 diabetes worldwide, and approximately two-thirds of deaths in people with type 2 diabetes in the US are caused by cardiovascular disease.
Dapaglifozin and vildagliptin impact cardio-metabolic processes differently.
Hypoglycemia was associated with early and late prothrombotic changes in the ﬁbrin network in individuals with type 2 diabetes.
Insulin products chart with pharmacokinetic properties.
Insulin preparations categorized by rapid-, short-, intermediate- and long-acting. Information such as the route, administration as well as the mixing of insulins is provided.
Diabetic complications were more prevalent in patients with both sickle-cell trait and T2D than in patients with T2D alone.
The ADA and the AHA launch a long-term awareness and education initiative for the prevention of deaths due to cardiovascular complications in patients with T2D.
Patients with both Parkinson disease and type 2 diabetes were more likely to have cardiovascular comorbidities than those with only Parkinson disease.
Patients who have the entire or left side of the colon removed show increased risk for developing type 2 diabetes in the 18 years following surgery.
For adults with type 2 diabetes, plant-based diets can improve psychological health, quality of life, hemoglobin A1c levels, and weight.
Early detection of lipidome characteristics could help identify the early onset of type 2 diabetes.
In recognition of National Diabetes Education Week, Endocrinology Advisor compiled a list of resources to assist clinicians when educating patients with diabetes about their condition.
Intensive BP control and fenofibrate use in patients with T2D who are at high risk for CVD may increase the risk for adverse kidney events.
The impurity was identified following laboratory testing conducted by the Food and Drug Administration (FDA); this is the first non-valsartan product that the Agency has found to contain NDEA.
Access to ready-to-eat outlets that sell food for instant consumption is associated with greater risk for type 2 diabetes.
Treatment with bardoxolone methyl resulted in significant weight loss and showed no evidence of muscle wasting in patients with type 2 diabetes and stage IV chronic kidney disease.
The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.
Hyperglycemia, obesity, and hypertriglyceridemia in type 2 diabetes are negatively related to indices of cardiovascular autonomic neuropathy.
Compared with women who experience normal or late menopause, women who experience early natural menopause have a shorter life expectancy and spend fewer years without type 2 diabetes.
LY3298176, a dual GIP and GLP-1 receptor agonist, showed significantly better efficacy than dulaglutide with regard to glucose control and weight loss in type 2 diabetes.
Type 2 diabetes is an independent risk factor for sudden cardiac arrest and death in patients with coronary artery disease with preserved ejection fraction.
Researchers found that higher levels of fatty acid biomarkers 15:0, 17:0, and trans-16:1n7 were inversely associated with risk for T2D.
Gastric banding and metformin resulted in similar improvements in insulin sensitivity in moderately obese adults with impaired glucose tolerance or mild T2D over a 2-year period.
There was not a clinically relevant association between DPP-4 inhibitors or GLP-1 receptor agonists and depression or self-harm in type 2 diabetes.
Individuals who develop diabetes or prediabetes have elevated fasting plasma glucose (FPG) at least 10 years before diagnosis.
Researchers analyzed how improvements in metabolic syndrome may impact the risk of developing type 2 diabetes and cardiovascular disease in patients with prediabetes.
A growing body of research highlights the important role of bone in glucose metabolism.
For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery.
Medically supervised, therapeutic fasting regimens can help reverse type 2 diabetes (T2D) and minimize the need for pharmacological interventions.
Quick Take: Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
Glucagon-like peptide-1 (GLP-1) potentiates the release of insulin from pancreatic beta cells in a glucose-dependent manner.
WHO guidelines recommend selecting sulfonylureas as the single best second-line agent for Type 2 Diabetes Mellitus (T2DM) patients.
Quick Take: Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomized, placebo-controlled trial
There is a strong relationship between body weight and the risk of developing diabetes.
Greater variation of fasting plasma glucose over time is associated with an increased risk of developing type 2 diabetes.
Study results indicated that sitagliptin showed greater glycemic efficacy than dapagliflozin treatment.
Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.
For patients with type 2 diabetes and existing cardiovascular disease, albiglutide results in fewer cardiovascular events.
For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.
Risk for type 2 diabetes, ischemic heart disease, and peripheral vascular disease was elevated among patients with psoriatic arthritis compared with the general population.
In this new analysis, researchers looked at the long-term effects of the drug on diabetes prevention and remission in these patients.
Recommendations in the report highlight the importance of patient-centered decision making for glycemic management and improving diet and exercise for patients with T2D.
Standard pen needles have an outer cover and removable inner needle cover, while safety pen needles have an outer cover and a fixed inner needle shield that is not removed before an injection.
Obesity is associated with loss of disease-free years irrespective of position in the social hierarchy and lifestyle.
Combination therapies of basal insulin with either vildagliptin or lixisenatide are similarly effective at producing glycemic control improvements.
Clusters of type 2 diabetes loci and traits have been identified.
Findings from the study showed a graded association between shorter average sleep duration and higher HbA1c concentrations among participants with diabetes.
Substituting processed red meat with poultry or fish and replacing total red meat with fish were associated with a lowered risk for type 2 diabetes.
Compared with the general population, patients with type 2 diabetes are at a 35% to 60% greater risk for atrial fibrillation.
Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.
Investigators assessed the time in range according to a continuous glucose monitor and the risk for diabetic retinopathy.
Investigators examined the effects of insulin glargine 300 U/mL vs insulin glargine 100 U/mL on glycated hemoglobin, hypoglycemia, and body weight change.
Investigators examined patient factors that affect the use of diabetes medication in patients with type 2 diabetes.
Researchers aimed to determine whether variations in phosphocreatine recovery rates were marked by distinct epigenomic muscle profiles that could be seen prior to training.
The high prevalence of obstructive sleep apnea syndrome in both type 1 and type 2 diabetes may favor screening in these patients.
Endocrinology Advisor interviewed experts to explore mechanisms, clinical implications, and research needs pertaining to the diabetes-dementia link.
The prevalence of type 1 and type 2 diabetes is 0.5 and 8.5 percent, respectively, among U.S. adults.
SGLT-2i exhibited superior effects in terms of weight loss and did not increase the risk for hypoglycemia in dual therapy with sulfonylurea.
HbA1c levels following left ventricular assist device implantation were statistically significantly lower than before surgery.
Investigators examined the effects of a 12-month collaborative care program for patients with late-life depression on the 9-year incidence of diabetes in older individuals.
Researchers suggest complement pathway activation plays a role in diabetic kidney disease progression in people with proteinuria.
Investigators examined the rates and risk factors for type 2 diabetes in individuals with chronic kidney disease.
The affordability and availability of diabetes medications across multiple regions of the word were examined, along with the effects on the use of medications.
Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.
Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes among multiethnic individuals.
Individuals with type 2 diabetes intensifying within 12 months of the index date had a significantly shorter median time from intensification to glycemic control.
Researchers concluded noninferiority between two basal insulin analogs after comparing safety and efficacy end points.
The authors searched for randomized placebo-controlled trials (December 1, 2008 to November 24, 2017) involving 3 pharmacologic classes of antidiabetic medications to compare the effects of these agents on the risk of hospitalization for HF in T2DM patients.
Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes.
Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.
Researchers conducted a retrospective analysis to determine whether second-line treatment options sulfonylureas, DPP-4 inhibitors, and thiazolidinediones were associated with reduced HbA1c levels.
Endocrinology Advisor Articles
- Testosterone Use Remains High Among Men With Coronary Artery Disease
- Insulin Analogs vs Regular Human Insulin for Type 2 Diabetes
- Primary Characteristics of PCOS Predictive of Obstetric Complications
- Trends in Bisphosphonate Use and Hip Fracture Rates in Denmark
- Maternal Thyroid Function in Pregnancy Linked to Childhood Risk for Disease
- ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care
- Sleep Habits Affect Insulin Sensitivity in Adolescents With Overweight, Obesity
- Levothyroxine Associated With Increased Mortality in Patients With Heart Failure
- Head-to-Head Comparison of Professional vs Personal CGM Systems in T1D
- Dual vs Triple Therapy for Metformin Treatment Intensification in Type 2 Diabetes
- Risk for Congenital Heart Defects in Offspring of Mothers With Obesity
- Is the MiniMed 670G System Safe for Children With Type 1 Diabetes?
- Gender-Affirming Hormonal Treatment and Long-Term Bone Safety
- Obesity Linked to Lower Gray Matter Brain Volume
- No Evidence for Health Benefits of Nonsugar Sweeteners