Type 1 Diabetes

Calcium Channel Blocker May Benefit Patients With Type 1 Diabetes

Calcium Channel Blocker May Benefit Patients With Type 1 Diabetes

By

For this study, researchers conducted a randomized, double-blind, placebo-controlled Phase 2 trial (N=24) to assess the efficacy and safety of adding oral verapamil for 12 months to a standard insulin regimen in adults with recent-onset type 1 diabetes (age range: 18 to 45 years).

1996 to 2013 Saw Large Increase in Diabetes Spending

1996 to 2013 Saw Large Increase in Diabetes Spending

Increased spending per encounter has been the biggest driver of overall rise in spending.

Oral Insulin Choline, Geranate Ionic Liquid Shows Promise

Oral Insulin Choline, Geranate Ionic Liquid Shows Promise

Significant, sustained decrease in blood glucose levels with low insulin doses of 3 to 10 U/kg.

Prevention Program May Reduce Distress, Depression in Adolescents With T1D

Prevention Program May Reduce Distress, Depression in Adolescents With T1D

Investigators examined the effect of the Penn Resilience Program for type 1 diabetes on diabetes-related distress, depressive symptoms, resilience, diabetes self-management, and glycemic control in a cohort of adolescents.

Two Phases of C-Peptide Decline Identified in Type I Diabetes

Two Phases of C-Peptide Decline Identified in Type I Diabetes

By

Identifying phases of C-peptide decline may be valuable for understanding β-cell survival.

Diabetes Risk Associated With Cirrhosis, Not Chronic HCV Infection, in HIV+ Patients

Diabetes Risk Associated With Cirrhosis, Not Chronic HCV Infection, in HIV+ Patients

By

Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.

Most Teens, Young Adults With Type 1 Diabetes Report Stigma

Most Teens, Young Adults With Type 1 Diabetes Report Stigma

Stigma is associated with two-fold higher odds of poor glycemic control after adjustment for confounders.

Mini-Dose Glucagon Helps Prevent Exercise-Induced Hypoglycemia in T1D

Mini-Dose Glucagon Helps Prevent Exercise-Induced Hypoglycemia in T1D

By

Mini-dose glucagon was as effective as glucose tablets for preventing hypoglycemia and may result in less post intervention hyperglycemia.

ISPAD Issues Consensus Statement on Diabetic Ketoacidosis and Hyperglycemia

ISPAD Issues Consensus Statement on Diabetic Ketoacidosis and Hyperglycemia

By

ISPAD recommends adjustments for fluid management regarding rehydration rates in children and adolescents with diabetes ketoacidosis.

ADA: T1D, T2D, GDM Before 26 Weeks Tied to Higher ASD Risk

ADA: T1D, T2D, GDM Before 26 Weeks Tied to Higher ASD Risk

Study shows increased risks of autism spectrum disorder in association with types 1, 2, gestational diabetes.

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

By

Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.

Dual-Hormone Artificial Pancreas Reduces Glucose Variability in T1D

Dual-Hormone Artificial Pancreas Reduces Glucose Variability in T1D

By

Investigators conducted a randomized crossover comparison of 2 dual-hormone artificial pancreas systems — one with rapid insulin and amylin, and another with regular insulin and amylin — with a rapid insulin-alone artificial pancreas.

Improved Glycemic Control With Closed-Loop Insulin Delivery System

Improved Glycemic Control With Closed-Loop Insulin Delivery System

By

Researchers conducted a randomized, open-label trial to assess the effect of an automated closed-loop insulin delivery system on glycemic control in hospitalized patients.

Technosphere Inhaled Insulin Improves Glycemic Control in Type 1 Diabetes

Technosphere Inhaled Insulin Improves Glycemic Control in Type 1 Diabetes

By

Patients were randomly assigned to receive insulin aspart or Technosphere inhaled insulin.

MiniMed 670G System Approved for Use in Younger Patients With T1D

MiniMed 670G System Approved for Use in Younger Patients With T1D

By

The MiniMed 670G system measures glucose levels every 5 minutes and automatically adjusts insulin delivery to avoid highs and lows.

Safety and Performance of Omnipod HCL for Children With Type 1 Diabetes

Safety and Performance of Omnipod HCL for Children With Type 1 Diabetes

By

In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.

Long-Term Sotagliflozin Safe, Effective as Adjunct Therapy to Insulin in Type 1 Diabetes

Long-Term Sotagliflozin Safe, Effective as Adjunct Therapy to Insulin in Type 1 Diabetes

By

After insulin optimization, participants with type 1 diabetes were randomly assigned to placebo, sotagliflozin 200 mg, or sotagliflozin 400 mg with insulin.

Chronic Kidney Disease More Common in Type 2 Diabetes Than in Type 1 Diabetes

Chronic Kidney Disease More Common in Type 2 Diabetes Than in Type 1 Diabetes

By

Investigators examined the prevalence of chronic kidney disease in adults with type 1 diabetes compared with type 2 diabetes.

Preventing Hypoglycemia During Exercise in Type 1 Diabetes on CSII

Preventing Hypoglycemia During Exercise in Type 1 Diabetes on CSII

By

Reducing basal insulin delivery by 50%-80% 90 minutes before aerobic exercise better prevents hypoglycemia risk vs basal suspension or disconnection at exercise onset.

Implantable Continuous Glucose Monitoring Device Safe, Effective for Adolescents

Implantable Continuous Glucose Monitoring Device Safe, Effective for Adolescents

By

The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.

Treatment for Necrobiosis Lipoidica Gets Orphan Drug Designation

Treatment for Necrobiosis Lipoidica Gets Orphan Drug Designation

By

The FDA has granted Orphan Drug Designation to PCS499 (Processa Pharmaceuticals) for the treatment of necrobiosis lipoidica.

Study suggests that diabetes can be accurately diagnosed from a single blood sample

Single blood sample looking at fasting glucose and HbA1c was a key predictor of subsequent diagnosis of diabetes.

AMA: Federal Government Must Tackle Rising Insulin Prices

AMA: Federal Government Must Tackle Rising Insulin Prices

U.S. officials need to take action to control spiking insulin prices, the American Medical Association says.

Adjunctive Metformin for Insulin Resistance in T1D: A Clinical Perspective

Adjunctive Metformin for Insulin Resistance in T1D: A Clinical Perspective

By

Although metformin has been studied in randomized trials as adjunctive therapy to insulin in individuals with type 1 diabetes, further investigation in the form of outcomes trials is necessary to assess risks vs benefits.

T1D Self-Management Varies With Adult Developmental Stages

T1D Self-Management Varies With Adult Developmental Stages

Researchers examined patterns of diabetes self-management behaviors and predictors of glycemic control in 7,153 adults enrolled in the Type 1 Diabetes Exchange clinic registry.

Stressful Life Events in Childhood and Development of Type 1 Diabetes

Stressful Life Events in Childhood and Development of Type 1 Diabetes

By

Children of parents experiencing stressful and severe life events in early childhood may be at risk for type 1 diabetes developing.

Asymptomatic Hypoglycemia Risk With Frequent Hypoglycemia in T1D

Asymptomatic Hypoglycemia Risk With Frequent Hypoglycemia in T1D

By

Investigators recorded hypoglycemic symptoms and monitored blood sugar levels by continuous glucose monitoring for 6 days.

Oral T1D Treatment Zynquista to Be Reviewed by FDA

Oral T1D Treatment Zynquista to Be Reviewed by FDA

By

The NDA was supported by data from the Phase 3 inTandem clinical trial program which assessed the safety and efficacy of Zynquista in ~3000 adults with inadequately controlled type 1 diabetes.

Individuals With Type 1 Diabetes See Improvement With Continuous Glucose Monitoring

Individuals With Type 1 Diabetes See Improvement With Continuous Glucose Monitoring

By

Investigators seek to determine he effects of continuous glucose monitoring on daytime and nocturnal hypoglycemia in patients with type 1 diabetes.

Sign Up for Free e-Newsletters



CME Focus