Type 1 Diabetes Archive
Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.
Individuals with higher executive function performance at baseline experienced slower increases in HbA1c.
Investigators assessed the effect of complication burden and concurrent risk factors level on the risk of developing further microvascular complication.
Although the association between type 2 diabetes and schizophrenia is well established, the link between type 1 diabetes and schizophrenia is less clear.
Investigators used data from the National Health Interview Survey and follow-up mortality data to estimate trends and disparities in CVD.
Excess cardiovascular risk varies with age at diagnosis of type 1 diabetes.
Diabetes and smoking are vascular risk factors associated with hippocampal calcification in older patients with memory issues.
The most prevalent complication was sexual dysfunction reported by both women and men, followed by urinary incontinence in women and low sexual desire in men.
WHO has developed guidelines for selecting therapy for treatment intensiﬁcation in type 2 diabetes and on the use of insulin in type 1 and 2 diabetes in resource-poor settings.
Investigators sought to determine whether participants who were followed-up before their diagnosis of diabetes had improved metabolic control afterward.
Significant improvement for older adults with depression, COPD; diabetes, cardiovascular disease.
Researchers from the University of Southern California in Los Angeles examined the impacts of Medicaid expansion on access to diabetes medications.
The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.
The PedsQL 3.2 can assist in identify new and existing therapeutic interventions for individuals with different diabetes-specific health-related quality of life profiles.
Among the many conditions that may co-occur with diabetes, eating disorders are common.
Investigators examined whether age of onset of type 1 diabetes affects mortality and cardiovascular risk.
Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.
Investigators examined safety and efficacy of adjunct therapy to insulin for patients with type 1 diabetes who are not adequately controlled.
It is critical for us to remember that children are not little adults. Pediatric-onset diabetes is different from adult-onset diabetes due to its distinct epidemiology, pathophysiology, developmental considerations, and response to therapy.
High Albumin-to-Creatinine Ratio Associated With Increased Risk for Microalbuminuria and Future CVD in Adolescents
The association between albumin-to-creatinine ratio and risk for diabetic nephropathy and CVD was examined over 2 to 4 years.
More than 25 percent of older U.S. adults with diabetes use some type of complementary and alternative medicine.
Investigators compared 2 interventions to reduce diabetes distress and improve glycemic control in patients with T1D.
Interruptions in private health insurance coverage are common among U.S. adults with type 1 diabetes and are associated with an increase in glycated hemoglobin and in use of acute care services.
Investigators evaluate the performance of the G6 factory-calibrated continuous glucose monitoring system over 10 days.
For patients with asymptomatic left ventricular systolic dysfunction (ALVSD), those with diabetes have increased risk of heart failure development and hospitalization.
Investigators aim to identify risk factors for hippocampal calcifications and to investigate the relationship between hippocampal calcifications and cognitive function.
Ambulatory blood pressure monitoring in addition to office readings may effectively be able to identify individuals who are at high risk for CVD in T1D.
Investigators examined the effects of antithymocyte globulin with or without pegylated granulocyte colony-stimulating factor on β-cell function and HbA1C.
Investigators examined whether incretin-based therapies increase the risk for diabetic retinopathy compared with other antihyperglycemic agents.
Particulate matter (PM) with a diameter of less than 2.5 micrograms per cubic meter of air (PM2.5) makes a substantial contribution to the burden of diabetes.
The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function.
For this study, researchers conducted a randomized, double-blind, placebo-controlled Phase 2 trial (N=24) to assess the efficacy and safety of adding oral verapamil for 12 months to a standard insulin regimen in adults with recent-onset type 1 diabetes (age range: 18 to 45 years).
Increased spending per encounter has been the biggest driver of overall rise in spending.
Significant, sustained decrease in blood glucose levels with low insulin doses of 3 to 10 U/kg.
Investigators examined the effect of the Penn Resilience Program for type 1 diabetes on diabetes-related distress, depressive symptoms, resilience, diabetes self-management, and glycemic control in a cohort of adolescents.
Identifying phases of C-peptide decline may be valuable for understanding β-cell survival.
Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.
Stigma is associated with two-fold higher odds of poor glycemic control after adjustment for confounders.
Mini-dose glucagon was as effective as glucose tablets for preventing hypoglycemia and may result in less post intervention hyperglycemia.
ISPAD recommends adjustments for fluid management regarding rehydration rates in children and adolescents with diabetes ketoacidosis.
Study shows increased risks of autism spectrum disorder in association with types 1, 2, gestational diabetes.
CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy
Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.
Investigators conducted a randomized crossover comparison of 2 dual-hormone artificial pancreas systems — one with rapid insulin and amylin, and another with regular insulin and amylin — with a rapid insulin-alone artificial pancreas.
Researchers conducted a randomized, open-label trial to assess the effect of an automated closed-loop insulin delivery system on glycemic control in hospitalized patients.
Patients were randomly assigned to receive insulin aspart or Technosphere inhaled insulin.
The MiniMed 670G system measures glucose levels every 5 minutes and automatically adjusts insulin delivery to avoid highs and lows.
In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.
After insulin optimization, participants with type 1 diabetes were randomly assigned to placebo, sotagliflozin 200 mg, or sotagliflozin 400 mg with insulin.
Investigators examined the prevalence of chronic kidney disease in adults with type 1 diabetes compared with type 2 diabetes.
Reducing basal insulin delivery by 50%-80% 90 minutes before aerobic exercise better prevents hypoglycemia risk vs basal suspension or disconnection at exercise onset.
The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.
The FDA has granted Orphan Drug Designation to PCS499 (Processa Pharmaceuticals) for the treatment of necrobiosis lipoidica.
U.S. officials need to take action to control spiking insulin prices, the American Medical Association says.
Children of parents experiencing stressful and severe life events in early childhood may be at risk for type 1 diabetes developing.
Researchers examined patterns of diabetes self-management behaviors and predictors of glycemic control in 7,153 adults enrolled in the Type 1 Diabetes Exchange clinic registry.
Investigators recorded hypoglycemic symptoms and monitored blood sugar levels by continuous glucose monitoring for 6 days.
Investigators seek to determine he effects of continuous glucose monitoring on daytime and nocturnal hypoglycemia in patients with type 1 diabetes.
The NDA was supported by data from the Phase 3 inTandem clinical trial program which assessed the safety and efficacy of Zynquista in ~3000 adults with inadequately controlled type 1 diabetes.
Investigators examined glycemic control variations in 8 high-income countries from multicenter registries in children with type 1 diabetes.
For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia.
For children and adults with type 1 diabetes, consuming a very low-carbohydrate diet is associated with exceptional glycemic control.
Upon review of the proposed supplemental New Drug Application (sNDA), the FDA has determined that the communication plan is no longer needed as an element of the REMS to ensure the benefits of Afrezza outweigh its risks.
Brief structured education in addition to informed support in active insulin dose self-adjustment underpinned by targeted self-monitoring of blood glucose lead to sustained falls in severe hypoglycemia rates in individuals at high risk.
Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D
The study highlights mitochondrial and autophagic differences in the muscles of young adults with type 1 diabetes with moderate glycemic control who exceed recommended activity levels.
The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.
Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.
For patients with type 1 diabetes, artificial pancreas treatment is efficacious, increasing the proportion of time spent in the near normoglycemic range.
Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle.
Awareness of ASD and its manifestations and comorbidities remain imperative in the treatment of T1D, as both conditions require long-term medical follow-up to continue improving diabetes care and metabolic control outcomes.
The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.
For adults with type 1 diabetes with suboptimal control despite using multiple insulin injections, continuous glucose monitoring seems cost-effective, with improved glucose control.
Telemedicine could provide real-time feedback loop and allow pharmacists to help patients self-manage.
Young adults with type 1 diabetes have altered neural responses during working memory processing.
IPITA and EPITA held a workshop to develop consensus for a joint statement on the definition of function and failure of current and future forms of β-cell replacement therapy.
Researchers conducted a systematic literature review to identify studies on cognitive function in children with type 1 diabetes.
Anti-osteoporotic medications (mainly bisphosphonates) seem to equally prevent bone loss, especially in the lumbar spine, in patients with diabetes compared with patients without diabetes.
Early treatment of cardiovascular disease risk factors such as dyslipidemia and hypertension will have long-term benefits with low risk and cost and should be more widely used in pediatric type 1 diabetes care.
There are significant improvements in health-related quality of life following islet transplantation in patients with type 1 diabetes complicated by severe hypoglycemia.
Researchers assessed the safety and accuracy of an implantable continuous glucose measurement in adults diagnosed with type 1 and type 2 diabetes.
Study provided evidence of significant differences in median serum concentrations of circulating adipose-related inflammatory biomarkers across the main diabetes types.
The FDA reviewed data for the device through the de novo premarket review pathway, a regulatory pathway for novel, low-to-moderate-risk devices that are not substantially equivalent to an already legally marketed device.
Sanofi announced that the Food and Drug Administration (FDA) has approved Toujeo (insulin glargine 300 Units/mL) Max SoloStar, a long-acting insulin pen that holds 900 Units of Toujeo and provides up to 160 Units/mL per injection.
Researchers assessed whether alcohol intake affects response to glucagon in individuals with type 1 diabetes.
The NDA is based on results from a large placebo-controlled, phase 3 trial that included 1402 patients with type 1 diabetes who were receiving insulin therapy.
Researchers assessed differences in glycemic control, major cardiovascular risk factors, diabetes-related complications, sexual dysfunction prevalence, and endothelial function in young men and women with type 1 diabetes.
For pregnant women with type 1 diabetes, a closed-loop system is associated with comparable glucose control and significantly less hypoglycemia than sensor-augmented pump therapy.
Research findings indicate improved glycemic outcomes in children with T1D using the MiniMed 670G system, similar to those observed for adolescents and adults.
Researchers assessed racial and ethnic differences in outcomes among patients in the first 3 years following diagnosis of type 1 diabetes.
Study found that the absence of proliferative diabetic retinopathy in those with stage 3b chronic kidney disease is associated with a lower prevalence of cardiovascular disease in patients with long duration of type 1 diabetes.
Study suggests that single-hormone artificial pancreas systems may be sufficient for overnight control even in a high-risk group of hypoglycemia-unaware participants with documented nocturnal hypoglycemia.
High-quality studies are needed to determine whether tight intrapartum glycemic control is superior to more relaxed glycemic targets intrapartum for women with diabetes in pregnancy.
Researchers calculated the hazard ratio of ADHD in offspring of patients with type 1 diabetes compared with the general population.
For youth with type 1 diabetes, disordered eating behaviors are associated with higher hemoglobin A1c but not with measures of glycemic variability.
Higher rates of operative delivery and falling gestational age at delivery suggest that this is either reflected by, or despite, increasing obstetric intervention.
Transcription factor 7 like 2 genetic variants contribute to phenotypic heterogeneity of type 1 diabetes.
Results from a study investigating diabetes and migraine in the Norwegian population show that type 1 and type 2 diabetes were significantly associated with a decreased risk for migraine.
Patients with diabetes had higher rates for all 19 infection categories with the highest incidence rate ratios seen for bone and joint infections, sepsis, and cellulitis.
Weaning to a hydrolyzed formula did not reduce the risk of type 1 diabetes in children with an increased disease risk.
Children with T1D had statistically significantly higher prevalence rates of hypertension, hypercholesterolemia, and used more CV medication compared with a matched diabetes-free reference cohort in the period after the onset of diabetes.
Endocrinology Advisor Articles
- Testosterone Use Remains High Among Men With Coronary Artery Disease
- Insulin Analogs vs Regular Human Insulin for Type 2 Diabetes
- Primary Characteristics of PCOS Predictive of Obstetric Complications
- Trends in Bisphosphonate Use and Hip Fracture Rates in Denmark
- Maternal Thyroid Function in Pregnancy Linked to Childhood Risk for Disease
- ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care
- Sleep Habits Affect Insulin Sensitivity in Adolescents With Overweight, Obesity
- Levothyroxine Associated With Increased Mortality in Patients With Heart Failure
- Head-to-Head Comparison of Professional vs Personal CGM Systems in T1D
- Dual vs Triple Therapy for Metformin Treatment Intensification in Type 2 Diabetes
- Risk for Congenital Heart Defects in Offspring of Mothers With Obesity
- Is the MiniMed 670G System Safe for Children With Type 1 Diabetes?
- Gender-Affirming Hormonal Treatment and Long-Term Bone Safety
- Obesity Linked to Lower Gray Matter Brain Volume
- No Evidence for Health Benefits of Nonsugar Sweeteners