Generic Name and Formulations:
Triptorelin pamoate 22.5mg; lyophilized microgranules for ext-rel IM inj after reconstitution; contains mannitol.
Arbor Pharmaceuticals, LLC
Indications for TRIPTODUR:
Treatment of central precocious puberty.
<2yrs: not established. Give as IM inj in buttock or thigh. ≥2yrs: 22.5mg once every 24 weeks. Discontinue at appropriate time point for onset of puberty. Consider switching to alternative GnRH agonist if Triptodur dose is inadequate.
Use aseptic technique. Must administer under physician supervision. Initial transient rise in gonadotropins and sex steroids may result in increased signs/symptoms of puberty. Monitor LH and sex steroid levels at 1–2 months after treatment initiation, during, and with each subsequent dose. Assess height every 3–6 months and bone age periodically. Monitor for psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Renal or hepatic impairment. Discontinue if overdosage occurs. Nursing mothers.
Concomitant hyperprolactinemic drugs: not recommended. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs). May interfere with pituitary gonadotropic and gonadal function tests.
Inj site reactions, menstrual bleeding, hot flush, headache, cough, infections (eg, bronchitis, gastroenteritis, influenza, nasopharyngitis, otitis externa, pharyngitis, sinusitis, upper respiratory tract infection); psychiatric events, convulsions.
Endocrinology Advisor Articles
- Behavioral Weight Loss Interventions May Prevent Obesity
- Executive Function Predicts T1D Management Into Emerging Adulthood
- Association Between Urine Complement Proteins and Kidney Disease, Mortality in T2D
- Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes
- Rates of Incident Type 2 Diabetes in Chronic Kidney Disease
- Bioethics Concerns Should Be a Key Element in mHealth Technology Development
- Gestational Diabetes Associated With Increased Risk for Postpartum Depression
- High Prevalence of Obstructive Sleep Apnea Syndrome May Favor Screening in Diabetes
- Update on the T2D-Dementia Link: Interview With Experts
- Dozens of Medical Groups Join Forces to Improve Diagnoses