Cross-sex hormone therapy raises risk for vascular events in transgender women
1. Transgender women had higher rates of venous thrombotic events (VTE) with cross-sex hormones.
2. Similar rates of ischemic stroke and myocardial infarction were found among cisgender and transgender persons.
Study Rundown: Acute cardiovascular events are an important area of research with respect to transgender health and the process of medical treatment during transitioning. Hormone use may increase rates of ischemic stroke, VTE, and myocardial infarction. The authors of this study aimed to evaluate the incidence of these events in a group of transgender persons. Generally, it was found that cross-sex hormone therapy raises the risk for vascular events in transgender women. Participants were included from Kaiser Permanente in Georgia and northern and southern California. The main limitation of this study, however, was that the authors could not determine which transgender members received hormones outside of the Kaiser Permanente setting. This point limited further subgroup analyses within the study. Overall, study results suggested that further and more vigilant monitoring of cardiovascular risk factors in transgender women may be important for reducing vascular events.
Relevant Reading: Effects of Cross-Sex Hormone Treatment on Transgender Women and Men
In-Depth [retrospective cohort]: The authors conducted an electronic medical record-based cohort study with patients from 2006 to 2014. Ten male and ten female cisgender enrollees were matched to transgender participants based on terms of patient characteristics. Overall, a total of 2842 transfeminine and 2118 transmasculine members were included in this study. The authors found few differences in ischemic stroke and myocardial infarction amongst all groups analyzed in the study. However, it was observed that transgender women had higher rates of VTE compared to cisgender men and cisgender women. Specifically, the 2- year risk differences were 4.1 (95% CI, 1.6 to 6.7) and 3.4 (CI, 1.1 to 5.6) per 1000 persons relative to cisgender men and women, respectively.
©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.
Endocrinology Advisor Articles
- Diet Quality and Glycemic Control in Women With Gestational Diabetes
- Most Foods Containing Fructose Do Not Have Harmful Effect on Glycemic Control
- Effects of a Low-Carbohydrate Diet on Weight Loss Maintenance
- Hypothyroidism Treatment No Longer Available
- Endocrine-Disrupting Chemicals in Personal Care Products Linked to Early Puberty
- Normalized HbA1c Levels Facilitate Improved Neuropathy Outcomes in T2D
- Parental Perception of Child Weight Status Predicted by Child BMI z Scores
- Fear Impacts Quality of Life for Young Adults With Type 1 Diabetes
- Five-Year Efficacy Data Announced for Liletta Intrauterine System
- AMA Code of Medical Ethics Guides Physicians in Fighting Harmful Online Health Information