Ticlopidine HCl Tablets Rx
Generic Name and Formulations:
Ticlopidine HCl 250mg; tabs.
Various generic manufacturers
Indications for Ticlopidine HCl Tablets:
To reduce the risk of thrombotic stroke in selected patients intolerant of aspirin.
250mg twice daily with food.
Hematopoietic disorders including neutropenia, thrombocytopenia, or history of thrombotic thrombocytopenic purpura (TTP). Hemostatic or active bleeding disorders. Severe hepatic impairment.
Monitor for hematologic toxicity at baseline, every 2 weeks for the first 3 months, and for 2 weeks after discontinuation; test more frequently if signs of hematological changes occur. Discontinue if neutropenia or TTP occur. Renal or hepatic impairment. Bleeding risk (eg, ulcers). Discontinue 10–14 days before surgery. Hyperlipidemia. Pregnancy (Cat.B). Nursing mothers: not recommended.
Platelet aggregation inhibitor.
Discontinue anticoagulants, fibrinolytics before use. Avoid aspirin. Potentiates aspirin, NSAIDs, anticoagulants, antipyrine, theophylline. Antacids reduce absorption. May be potentiated by cimetidine. Monitor phenytoin. May antagonize digoxin. Caution with propranolol, drugs that increase risk of bleeding, and drugs metabolized by CYP450.
Diarrhea, GI upset, rash, neutropenia, pruritus, dizziness, anorexia, abnormal liver function tests, bleeding complications, hyperlipidemia, TTP, aplastic anemia, agranulocytosis, other blood dyscrasis, jaundice.
Formerly known under the brand name Ticlid.
Endocrinology Advisor Articles
- Diet Quality and Glycemic Control in Women With Gestational Diabetes
- Most Foods Containing Fructose Do Not Have Harmful Effect on Glycemic Control
- Effects of a Low-Carbohydrate Diet on Weight Loss Maintenance
- Sleep Quality in Women With Surgical vs Natural Menopause
- Unhealthy Lifestyle and Rotating Night Shifts Put Nurses at Higher Risk for T2D
- Hypothyroidism Treatment No Longer Available
- Obesity Subtype May Determine Outcomes After Bariatric Surgery
- Few Physicians Work in Practices That Use Telemedicine
- Skin Autofluorescence Predicts T2D, Heart Disease, Mortality
- ACC: Smoking Cessation Expert Decision Pathway Emphasizes Team-Based Support