Increased Primary Hyperparathyoridism Risk Linked to Weight in Women

HealthDay News — Body size seems to be associated with increased risk of primary hyperparathyroidism (P-HPTH) in women, according to a study published online in the Journal of Bone and Mineral Research.

Anand Vaidya, MD, from Brigham and Women’s Hospital in Boston, and colleagues examined whether greater body size correlated with increased risk for developing P-HPTH in women. The prospective cohort study involved 85,013 female participants in the Nurses’ Health Study I. Weight and BMI were assessed every 2 years from 1986 to 2012, and waist circumference (WC) was measured in 1986, 1996, and 2000. Validated biennial questionnaires were used to quantify dietary and demographic exposures.

During 2,128,068 person-years of follow-up, the researchers confirmed 491 incident cases of P-HPTH. For incident P-HPTH, the multivariable adjusted relative risks increased across WC quartiles relative to quartile 1 (Q1): Q2, 1.34 (95% CI, 0.97-1.86), Q3, 1.7 (95% CI, 1.24-2.31), and Q4, 2.27 (95% CI, 1.63-3.18); P-trend <.001. Across quartiles of weight there were similarly increasing multivariable adjusted risks for incident P-HPTH relative to Q1: Q2, 1.23 (95% CI, 0.92-1.65), Q3, 1.63 (95% CI, 1.24-2.14), and Q4, 1.65 (95% CI, 1.24-2.19); P-trend <.001. Across quartiles of BMI there was a similar but nonsignificant trend (P-trend =.07)

“In summary, body size may be an independent and modifiable risk factor for developing P-HPTH in women,” the authors write.

Related Articles


Vaidya A, Curhan GC, Paik JM, Wang M, Taylor EN. Body size and the risk of primary hyperparathyroidism in women: a cohort study [published online May 10, 2017]. J Bone Miner Res. doi: 10.1002/jbmr.3168