In a study, patients receiving cinacalcet under supervision 3 times per week after dialysis rather than after daily self-administration showed improvement in their parathyroid hormone levels.
Rheumatoid arthritis is associated with an increased occurrence of autoimmune thyroid disease, indicated by an increased risk of developing autoimmune thyroid disease before RA diagnosis.
The best overall performance was that of the ACR Thyroid Imaging Reporting and Data System, which classified more than half of the requested biopsies as unnecessary.
Obesity was not associated with more aggressive clinicopathologic features of thyroid cancer.
Thyroid stimulating hormone levels at diagnosis and the L-thyroxine dose through treatment may distinguish between permanent and transient congenital hypothyroidism.
Findings do not support the routine use of thyroid hormone therapy in adults with subclinical hypothyroidism.
Excess cardiovascular disease mortality persisted for many years after thyroid-ablative treatment in patients who received radioactive iodine who did not become hypothyroid.
The rate of pre-eclampsia and preterm delivery was higher in medically managed patients with hyperparathyroidism.
Adherence to the 2015 recommendation from ATA — to use lobectomy rather than complete thyroidectomy for low-risk differentiated thyroid cancer — is increasing.
Childhood radiation-induced thyroid cancer does not affect all-cause mortality compared with healthy individuals.
Malignancy was more common in children with thyroid nodules classified as indeterminate by BSRTC criteria compared with adults.
The BABA robotic thyroidectomy technique appears to be safe, with excellent outcomes in benign and malignant thyroid disease.
Ethanol sensitization before radiofrequency ablation of benign thyroid nodules reduced time, ablation energy, and complications compared with conventional ablation.
Recombinant Human Thyrotropin vs Thyroid Hormone Withdrawal After Radioiodine Therapy in Thyroid Cancer
Outcomes after radioiodine therapy are similar after preparation with either recombinant human thyrotropin or thyroid hormone withdrawal.
Most imaging centers in the United States fail to analyze lateral neck lymph nodes during preoperative ultrasounds in patients with thyroid cancer.
Current trial evidence does not support the treatment of subclinical hypothyroidism diagnosed in pregnancy.
Total thyroxine in newborns was measured by heel-stick blood spot test.
TGF-β1and cortisol displayed both immuno-modifying and -suppressive roles with regard to thyroid autoantibodies.
Male thyroid cancer survivors have a nearly 50 percent higher risk of developing CVD than female survivors within five years of cancer diagnosis.
LOXO-292 is being evaluated in the ongoing Phase 1/2 LIBRETTO-001 clinical trial.
Compared with uninfected individuals, people with HIV controlled with combination antiretroviral therapy are not at increased risk of developing thyroid dysfunction.
Calling it 'cancer' rather than 'lesions' or 'abnormal cells' could increase anxiety, likelihood of surgery.
Investigators assessed the quality of life of patients with hypothyroidism who were treated with levothyroxine and its association to demographics and clinical symptomatology.
The associations between thyroid hormone levels, body composition, and insulin resistance in euthyroid patients with normal thyroid ultrasound findings are examined.
Patients with higher levels of thyroid-stimulating hormone were more likely to experience atrial tachyarrhythmia after catheter ablation for atrial fibrillation.
There are 14 states that perform a routine second screening in infants at approximately 2 weeks of age.
Choice between total thyroidectomy or lobectomy has little effect on risk for thyroid cancer mortality.
The association between maternal thyroid function in early pregnancy and child neurodevelopment was examined.
Investigators reviewed cases of patients with multiple sclerosis treated with alemtuzumab to determine the type and frequency of thyroid dysfunction.
The device is indicated for ultrasound echo imaging, measurement, and analysis of the human body for general clinical applications including musculoskeletal, vascular, small parts (breast, thyroid), and lung imaging.
Postoperative Radioactive Iodine Ablation Effective in Reducing Disease Recurrence in Low-Risk Thyroid Cancer
Investigators reported outcomes of a randomized phase 3 trial that assessed the use of radioactive iodine following surgical resection in patients with low-risk thyroid cancer.
Investigators sought to assess the link between treatment for thyroid cancer and subsequent cardiac and vascular complications.
On laboratory tests, the authors identified an unusual endocrine hormonal profile, including pituitary hormones below reference intervals and gonadal and adrenal hormones above reference intervals.
Investigators assed the 2017 American College of Radiology Thyroid Imaging Reporting and Data System for categorizing malignancy in children with thyroid nodules.
In an orthotopic anaplastic thyroid cancer model, hypofractionated radiotherapy is superior to conventionally fractionated radiotherapy.
This study sought to further examine the association between migraine and subclinical hypothyroidism.
Investigators examined whether short-term treatment with an angiotensin II receptor blocker and/or vitamin D3 reduced PTH levels.
Investigators sought to determine whether smoking effects serum TSH levels in a healthy population.
Findings do not support a role for subclinical thyroid dysfunction as a biomarker for bone-related outcomes in older men.
Study data showed 57% of evaluable patients (N=23) had a partial response and 4% achieved a complete response. Among the 14 responders, 64% did not have significant tumor growths for ≥6 months.
Study is the first to reveal a higher prevalence of iodine deficiency and hypothyroidism in children receiving chronic parenteral nutrition.
Destructive thyroiditis was a frequently observed endocrine immune-related adverse event induced by nivolumab treatment and was significantly associated with the existence of anti-thyroglobulin antibodies and/or anti-thyroid peroxidase antibodies prior to treatment.
Researchers designed a cohort study to examine whether serum thyroid hormone levels within the reference range are predictive factors for developing metabolic syndrome in adults.
Shear wave elastography can be a useful tool in the preliminary diagnostics of parathyroid adenomas.
Treating Moderate to Severe Graves' Orbitopathy: Methylprednisolone Alone vs Combined With Mycophenolate
This study is the first to investigate the efficacy and safety of add-on mycophenolate to methylprednisolone for moderate to severe Graves' orbitopathy.
Levothyroxine treatment did not appear to improve pregnancy outcomes in women with thyroid autoantibodies undergoing in vitro fertilization and embryo transfer.
Antithyroid drug exposure during the first trimester was associated with an increased risk for congenital malformations.
Study raises the question of whether treatment with thyroid hormone replacement for individuals with TSH levels >2.5 mIU/L may be an economical first step in treating unexplained infertility.
Study showed that parathyroid hormone was a significant predictor of lumbar spine bone mineral density Z-score for pseudohypoparathyroidism 1B patients.
Survivors of thyroid cancer have a higher risk of developing age-associated diseases compared with patients who never had cancer, particularly if they were younger than 40 years at the time of diagnosis.
Study aimed to evaluate the benefits of levothytoxine treatment on pregnancy outcomes in subclinical hypothyroid pregnant women who are negative for thyroid peroxidase antibody.
Investigators aimed to determine strategies for improvement to reduce complications after thyroidectomy.
No clear effect in most cases of a second radioactive iodine (RAI) treatment in patients with differentiated thyroid cancer with biochemical or structural regional incomplete response to initial thyroidectomy and RAI therapy.
Thyroid ultrasonography, which may lead to the discovery of incidental nodules, anxiety, and high cost, is not required in evaluation for hypothyroidism.
The transoral endoscopic thyroidectomy vestibular approach can be a safe procedure in select patients, with outcomes similar to those of open thyroidectomy.
A 6.2-fold variation in thyroidectomy rates was noted throughout the US.
Both over- and undertreatment of congenital hypothyroidism can result in negative behavioral outcomes.
No regional or distant metastases developed during active surveillance in low-risk patients.
Irregular users of thyroxine were less likely to develop thyroid cancer compared to regular users.
Stroke risk with I-131 therapy for thyroid cancer was examined via 2 cohorts using 1:1 propensity score matching.
Maternal thyroid function and weight gain in early pregnancy were associated with hypothyroidism, but not hyperthyroidism.
Relapse risk was highest among patients with hypothyroidism.
After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.
Adult patients with obesity and hypothyroidism have lower-than-average sleep oxygen saturation.
Patients given teprotumumab were more likely to experience a response at 24 weeks vs placebo.
Thyroid cancer screening in asymptomatic adults was given a D recommendation because of the negative effects of screening outweighing any benefits.
Miscarriage risk before 20 weeks of gestation is higher among women with untreated subclinical hypothyroidism.
Data were collected from the Nurses' Health Study I to examine the relationship between BMI and primary hyperparathyroidism risk.
Patients with government subsidized or self-pay insurance were less likely to undergo thyroidectomy for thyroid cancer.
Increases in papillary thyroid cancer were most common between 1974 and 2013.
The pocket references and mobile apps will be updated as diagnostic tools and guidelines continue to improve.
Tirosint-SOL (levothyroxine sodium oral solution) should be available within the next 6 months.
The drug's approval was based on 2 successful phase 3 trials.
Women with subclinical hypothyroidism who undergo thyroid hormone treatment have a decreased risk of pregnancy loss, but may experience other pregnancy-related adverse outcomes.
Younger survivors of thyroid cancer are at increased risk for certain types of health problems later in life.
For patients with unresected anaplastic thyroid carcinoma, overall survival is poor, but radiation therapy dose is associated with improved survival.
Early detection and quick treatment with levothyroxine are essential in treating children with congenital hypothyroidism.
For patients with head and neck cancer receiving radiotherapy, thyroid dysfunction is a dose-related complication, with increased risk for female sex and concurrent chemotherapy.
Patients with fibromyalgia syndrome have high prevalence of anti-thyroid-stimulating hormone (TSH) receptor antibody (TRAb).
Widespread routine thyroid cancer screening can lead to overdiagnosis and overtreatment, according to the statement.
Aryl hydrocarbon receptor (AHR) and AHR ligands prevent formation of transforming growth factor (TGF)-β-dependent myofibroblast formation in thyroid eye disease.
In a 2-phase study of patients with autoimmune thyroid disease, researchers identified specific antibodies that may have lead to an elevated risk of autoimmune disorder development.
Does core-needle biopsy perform better than repeat fine-needle aspiration for evaluating thyroid nodules?
Researchers hypothesize that thyroid function affects dementia risk through nonvascular pathways.
SREAT, or Hashimoto's encephalopathy, may present in some cases with purely depressive symptoms.
Patients with thyroid hormone levels on the high end of the normal range in this study were more than twice as likely to die of sudden cardiac arrest.
Primary care physicians play an important role in identifying thyroid disease in children and adolescents, according to a review published in JAMA Pediatrics.
Researchers have identified estimates for risk of occult nodal disease of patients with papillary thyroid cancer who have undergone surgery.
More imaging tests after treatment does not always lead to an improvement in thyroid cancer patients' chances of survival.
Lower thyroid function was associated with a 1.24-fold higher risk for nonalcoholic fatty liver disease.
There were no effective therapeutic options for advanced thyroid cancer until 5 years ago.
Physicians present viewpoints for and against treatment of subclinical hypothyroidism in a 60-year-old patient.
A uniform standard for thyroid-stimulating hormone reference limits could lead to frequent misclassification and incorrect choices for therapy.
The recent increase may be caused by an 'epidemic of diagnosis,' not harmful tumors, researchers said.
Local-regional failure in well-differentiated thyroid cancer mostly occurs outside of 70 Gy volume and in peri-esophageal region.
The risk for complications was 87% higher when a surgeon's case load is1 thyroidectomy case a year.
However, nearly one-third of patients develop lifelong complications following thyroid surgery.
The use of certain antiepileptic drugs may cause alterations in thyroid hormone levels in patients with epilepsy.
The large study linking Agent Orange with adverse effects includes US veterans of the Korean War who also served in the Vietnam War.
Women with hyperthyroidism have increased breast cancer risk, while hypothyroidism is associated with decreased risk.
Endocrinology Advisor Articles
- Testosterone Use Remains High Among Men With Coronary Artery Disease
- Insulin Analogs vs Regular Human Insulin for Type 2 Diabetes
- Primary Characteristics of PCOS Predictive of Obstetric Complications
- Trends in Bisphosphonate Use and Hip Fracture Rates in Denmark
- Maternal Thyroid Function in Pregnancy Linked to Childhood Risk for Disease
- ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care
- Sleep Habits Affect Insulin Sensitivity in Adolescents With Overweight, Obesity
- Levothyroxine Associated With Increased Mortality in Patients With Heart Failure
- Head-to-Head Comparison of Professional vs Personal CGM Systems in T1D
- Dual vs Triple Therapy for Metformin Treatment Intensification in Type 2 Diabetes
- Risk for Congenital Heart Defects in Offspring of Mothers With Obesity
- Is the MiniMed 670G System Safe for Children With Type 1 Diabetes?
- Gender-Affirming Hormonal Treatment and Long-Term Bone Safety
- Obesity Linked to Lower Gray Matter Brain Volume
- No Evidence for Health Benefits of Nonsugar Sweeteners