Mifepristone may be an effective alternative to adrenalectomy in patients with hypercortisolism caused by primary bilateral macronodular adrenal hyperplasia.
Hypertension may be associated with degree of glucocorticoid suppression and peripheral activation in postmenopausal women.
Prevalence of diabetes is higher in patients with primary aldosteronism and was found to be related to suspected subclinical hypercortisolism.
Chronically high cortisol levels in Turner syndrome are linked to short stature, elevated total cholesterol levels, and possibly a greater risk for cardiovascular disease.
Autonomous cortisol secretion is common in patients with primary aldosteronism and is associated with increased risk for type 2 diabetes.
BACH2 is a major risk locus for Addison’s disease, according to a study published in the Journal of Internal Medicine.
Advances in genetics may hold the key to improving diagnosis and treatment of Cushing’s syndrome, but issues still remain.
Patients with adrenal tumors of intermediate phenotype or subclinical Cushing’s syndrome are at increased risk of cardiovascular events and mortality compared to those with stable non-secreting adrenal incidentalomas.
