Diagnosis and Management of Pituitary Incidentaloma
Patient evaluation, follow-up testing, and treatment differ based on lesion size and presence of hormone abnormalities with pituitary incidentalomas.
Growth Hormone Deficiency
How Does the Switch From Daily to Weekly Dosing Affect Growth Hormone Therapy Outcomes?
Switching from daily human growth hormone to once-weekly TransCon growth hormone treatment resulted in similar safety and efficacy outcomes in pediatric patients.
Long-Acting Therapy for Growth Hormone Deficiency Receives Orphan Designation
The FDA has granted Orphan Drug designation to TransCon hGH (lonapegsomatropin; Ascendis Pharma), a long-acting prodrug of somatropin, for the treatment for growth hormone deficiency.
Once-Weekly Treatment for Adult GH Deficiency Effective in Phase 3 Trial
A once-weekly growth hormone replacement therapy demonstrated superiority over placebo for patients with adult growth hormone deficiency.
Irisin Levels May Be Metabolic Biomarker for GH Replacement Therapy
Growth hormone replacement can raise irisin levels in children with growth hormone deficiency.
Normal Height Velocity Maintained With Reduced Growth Hormone Dose
Normal height velocity can be maintained in prepubertal children during the catch-up growth period by reducing growth hormone dosage by 50%.
Safety and Mortality Outcomes Following Pediatric Growth Hormone Therapy
Primary cancer rates and mortality risk were no higher for pediatric patients treated with growth hormone therapy.
Clonidine Testing Is Safe and Reliable for Diagnosing Growth Hormone Deficiency
Investigators examined the reliability of the clonidine test in children with short stature who had been evaluated for suspected growth hormone deficiency.
Higher Risk for Meningioma Linked to GH Treatment, Radiotherapy During Childhood
The risk for meningioma was not significantly higher in patients who did not receive radiotherapy.
Grote Clinical Decision Rule May Be Best for Monitoring Growth in Children
Investigators sought to improve growth-monitoring programs by examining existing algorithms and examined the effect of using WHO vs national growth charts on algorithm performance.
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