The discontinuation of denosumab is associated with increased bone turnover markers and bone loss, but prior treatment with bisphosphonates did not seem to prevent the development of these complications.
A biomechanical computed tomography program used to screen for osteoporosis appears to be a cost-effective alternative to standard care for adults age ≥65 years.
There is no association between insulin resistance and fracture risk in older adults without diabetes.
Lateral areal bone mineral density can identify microstructural heterogeneities that are independent of age and has advantages over anterior-posterior DXA scanning for fracture risk assessment.
Sequential therapy beginning with abaloparatide followed by alendronate is a cost-effective strategy for women at increased risk for fractures.
In a cohort of Norwegian men and women assessed for fragility fractures, over half had vertebral fractures, low trabecular bone score, or both.
Single and multiple fragility fractures significantly affect long-term health-related quality of life in older people.
Evaluation and treatment rates in men at risk for osteoporosis are strikingly low.
Patients with systemic lupus erythematosus were at greater risk for fractures compared with controls.
A meta-regression analysis indicated that greater improvements in BMD were strongly associated with greater reductions in fracture risk, especially in the vertebrae and hip.
