Despite the preponderance of CS in women of childbearing age and the likelihood of pregnancy triggering CS, the condition is often overlooked because of the overlap of pregnancy and hypercortisolism symptoms.
Plasma levels of the orexigenic neuropeptide agouti-related protein (AgRP) are elevated in Cushing disease, and it may be a marker of hypothalamic AgRP.
Although patients reach clinical and biochemical remission, patients exposed to hypercortisolism do not show functional remission.
Results from this single-arm, open-label study found that 30% of patients achieved normalization of mean urinary free cortisol (UFC) after 6 months of maintenance treatment with levoketoconazole, without a dose increase (P<.25).
The treatment goals for Cushing syndrome are to normalize cortisol levels, reverse clinical symptoms, and if possible to remove the secreting neoplasm.
Study assessed cardiovascular function, quality of life, and mental/physical health in overt and cured Cushing syndrome.
As a result of overlapping features with various other conditions, milder cases of Cushing’s syndrome present diagnostic challenges and may require careful observation as well as biochemical and imaging tests.
The analysis led to the identification of 4 potentially pathogenic missense variants in CABLES1.
Four-month-old developed iatrogenic Cushing’s syndrome after 6 weeks of intranasal dexamethasone ophthalmic solution.
Guideline focuses on surgical resection to normalize cortisol levels.
