Contraceptives Beneficial for Premature Ovarian Insufficiency
For women with premature ovarian insufficiency, continuous use of combined oral contraceptives is associated with increased BMD, similar to that seen with high-dose hormone therapy.
Androgen and Reproductive Disorders
Sustained Clinical Benefits Observed With Linzagolix in Uterine Fibroid Trials
Positive topline data were announced from two phase 3 studies evaluating the efficacy and safety of linzagolix (Yselty®; ObsEva) for the treatment of heavy menstrual bleeding due to uterine fibroids.
New Data Suggest 2 Distinct Subtypes of Polycystic Ovary Syndrome
A genetic analysis of nearly 900 women with polycystic ovary syndrome identified 2 distinct subtypes of the disease with unique genetic variants.
Clinically Meaningful Pain Reduction Observed With Relugolix in Endometriosis Trial
Positive topline results were announced from the phase 3 SPIRIT 1 study investigating relugolix (Myovant Sciences), in combination with estradiol and norethindrone acetate, in women with pain associated with endometriosis.
Effects of Insulin Sensitizers on Hormonal and Metabolic Parameters in PCOS
Combination therapy with insulin sensitizers may be superior to monotherapy for improvement of hyperandrogenemia and menstrual recovery in polycystic ovary syndrome.
The Role of Kisspeptin in In Vitro Fertilization Treatment
Kisspeptin might play a role in ovulation and successful pregnancy in patients with infertility who undergo in vitro fertilization.
FDA Approves Treatment for Heavy Menstrual Bleeding Due to Uterine Fibroids
The FDA has approved Oriahnn™ (elagolix, estradiol, and norethindrone acetate capsules; elagolix capsules; AbbVie) for the management of heavy menstrual bleeding associated with uterine leiomyomas (fibroids) in premenopausal women.
Early-Life Mortality Risk Higher in ART-Conceived Children
Compared with children who are naturally conceived, children who are conceived via assisted reproductive techniques (ART) may be at increased risk for mortality during their first year of life.
Estimates of Live Birth Rates for Second ART-Conceived Children
Researchers examined factors associated with returning to the use of assisted reproductive therapy for a second child and cycle-specific and cumulative live birth rates.
Nasal Gel Increases Testosterone, Maintains Semen Parameters
In a study, most symptomatic hypogonadal men treated with Natesto, a short-acting 4.5% nasal testosterone gel, attained normal testosterone levels at 6 months while preserving sperm counts.
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