Levoketoconazole Effectively Treats Endogenous Cushing Syndrome in Phase 3 Trial
According to results of the phase 3 SONICS trial, levoketoconazole is a safe and effective treatment option for patients with Cushing syndrome.
Adrenal
Sex Affects Clinical Presentation of ACTH-Dependent Cushing Syndrome
Researchers examined sex differences in clinical presentation and patient outcomes in ACTH-dependent Cushing syndrome.
Increase in HDL-C, Adiponectin Levels With Glucocorticoid Replacement Therapy
Glucocorticoid replacement therapy is associated with an increase in serum levels of adiponectin and high-density lipoprotein cholesterol.
Additional Cortisol Testing During Low-Dose ACTH Stimulation Test Can Reduce False Positives
Measuring cortisol levels at 15 and 60 minutes in addition to the standard 30 minutes can reduce false positives in standard low-dose ACTH stimulation testing with cosyntropin.
Recovery of HPA Axis Can Occur Late After Transsphenoidal Adenomectomy
Clinicians should periodically assess patients after transsphenoidal adenomectomy given that recovery of the hypothalamus-pituitary-adrenal axis can occur as late as 12 months postsurgery.
Signs and Symptoms of Adrenal Medullary Hyperplasia vs Pheochromocytoma
Patients with AMH without pheochromocytoma had milder symptoms compared with patients with pheochromocytoma only.
Adrenal Incidentalomas Rarely Grow, Change Hormone Function
Nonfunctioning adrenal tumors (NFATs) or adenomas causing mild autonomous cortisol excess (MACE) rarely show clinically relevant changes in size or hormone function.
Mifepristone an Effective Alternative to Surgery for Patients With Bilateral Macronodular Adrenal Hyperplasia
Mifepristone may be an effective alternative to adrenalectomy in patients with hypercortisolism caused by primary bilateral macronodular adrenal hyperplasia.
Hypertension Associated With Glucocorticoid Sensitivity and Activity in Women Without Hypercortisolism
Hypertension may be associated with degree of glucocorticoid suppression and peripheral activation in postmenopausal women.
Transsphenoidal Surgery Recommended for Cushing Disease With Inconclusive or Normal MRI
In the absence of clear evidence of a pituitary adenoma on imaging, there is some controversy regarding the best treatment for Cushing disease.
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