‘Excellent’ Outcomes and Room for Improvement in Pediatric Adrenocortical Carcinoma
Patients with stage II or IV disease did not fare as well as patients with stage I or III disease.
Adrenal
Autonomous Cortisol Secretion in Adrenal Incidentalomas Linked to Increased Mortality
Investigators sought to measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas.
Epigenetic Clock May Reveal Biological Aging After Cancer Treatment and Allow for Objective Measurement of Fatigue
Researchers found associations between epigenetic age acceleration, inflammation, and fatigue in cancer patients.
Primary Adrenal Insufficiency Management Is Aided by Genetic Diagnosis
A team of researchers conducted genetic analyses of children and adolescents with primary adrenal insufficiency of unknown etiology to provide insight into diagnosing this and other related conditions.
Osilodrostat Improves Signs and Symptoms Associated With Cushing Disease
A team of investigators conducted a phase 3, multicenter study with a double-blind, randomized withdrawal period to assess the effects of twice-daily osilodrostat in patients with Cushing disease.
Obesity Associated With Worse Outcomes in Patients With Adrenal Insufficiency
A team of investigators reviewed data from the 2018 Nationwide Inpatient Sample to assess the impact of obesity on outcomes in patients hospitalized for adrenal insufficiency.
Investigational Gene Therapy Fast Tracked for Congenital Adrenal Hyperplasia
BBP-631 is an adeno-associated virus 5 (AAV5) gene therapy designed to deliver a functional copy of the 21-hydroxylase gene to restore the body’s ability to produce cortisol and aldosterone.
Oral Corticosteroid Dose Management With Impaired Adrenal Function Evaluated
Patients with normal adrenal function are largely able to eliminate the use of oral corticosteroids or achieve a daily dose of 5 mg or less.
Medical and Surgical Management of Aldosteronism
The authors explore the etiology and clinical presentation of primary and secondary aldosteronism as well as medical and surgical treatment options.
Patients With Underlying Medical Conditions Now a Priority for COVID-19 Vaccination
In March, the Centers for Disease Control and Prevention launched phase 1c of its COVID-19 vaccine roll-out plan. Diabetes patients and patients with other underlying medical conditions are included on the list. Learn more in this article.
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