Measuring cortisol levels at 15 and 60 minutes in addition to the standard 30 minutes can reduce false positives in standard low-dose ACTH stimulation testing with cosyntropin.
Clinicians should periodically assess patients after transsphenoidal adenomectomy given that recovery of the hypothalamus-pituitary-adrenal axis can occur as late as 12 months postsurgery.
Patients with AMH without pheochromocytoma had milder symptoms compared with patients with pheochromocytoma only.
Nonfunctioning adrenal tumors (NFATs) or adenomas causing mild autonomous cortisol excess (MACE) rarely show clinically relevant changes in size or hormone function.
Mifepristone may be an effective alternative to adrenalectomy in patients with hypercortisolism caused by primary bilateral macronodular adrenal hyperplasia.
Hypertension may be associated with degree of glucocorticoid suppression and peripheral activation in postmenopausal women.
In the absence of clear evidence of a pituitary adenoma on imaging, there is some controversy regarding the best treatment for Cushing disease.
Prevalence of diabetes is higher in patients with primary aldosteronism and was found to be related to suspected subclinical hypercortisolism.
Adjusting threshold levels of 17-OHP to reflect gestational age and birth weight might be a safe and efficient strategy to improve screening for CAH in newborns.
Researchers reported that mean urinary-free cortisol (mUFC) normalization with Recorlev was similar in patients with and without diabetes.
