Generic Name and Formulations:
Pilocarpine (as HCl) 5mg, 7.5mg; tabs.
Indications for SALAGEN:
Dry mouth (xerostomia) due to radiotherapy for head and neck cancer or Sjogren's syndrome.
Cancer: Initially 5mg three times daily; range 15–30mg daily; max 10mg/dose. Sjogren's syndrome: 5mg four times daily. Moderate hepatic impairment for both: 5mg twice daily.
Uncontrolled asthma. When miosis is undesirable (iritis, narrow-angle glaucoma).
Severe hepatic impairment: not recommended. Cardiovascular disease. Controlled asthma. Chronic bronchitis. COPD. Cholethiasis. Biliary tract disease. Nephrolithiasis. Cognitive or psychiatric disorders. Activities requiring visual acuity. Pregnancy (Cat.C). Nursing mothers: not recommended.
Cardiac conduction disturbances with β-blockers. Potentiates parasympathomimetics. Antagonizes anticholinergics (eg, atropine, ipratropium).
Sweating, nausea, rhinitis, chills, flushing, urinary frequency, dizziness, asthenia, headache, abnormal vision.
Endocrinology Advisor Articles
- Soluble Klotho Levels Predictive of Kidney Failure in Type 2 Diabetes
- Clinicians May Be Overtreating Older Patients With Diabetes
- Comorbid and Pharmacologic Factors Increase Risk for Gastrointestinal Disorders in Diabetes
- Obesity Risk in Infants Born to Women With Diabetes
- Increased Risk for Mortality in People With Diabetes, CHD Taking Beta-Blockers
- Diabetes May Decrease Ability to Feel Acid Regurgitation
- Autism Does Not Affect Metabolic Control in Type 1 Diabetes
- Hormonal Contraceptives May Adversely Affect Psychological Health in Adolescent Girls
- Obesity Can Negatively Effect Liver in Children as Young as 8
- Recommendations Developed on Gender Equity in Medicine