Protamine sulfate Rx
Generic Name and Formulations:
Protamine sulfate 10mg/mL; soln for inj; preservative-free.
Fresenius Kabi USA
Indications for Protamine sulfate:
Treatment of heparin overdose.
Give by slow IV inj over 10 mins. Determine dose by coagulation studies; dose requirement decreases with time elapsed after heparin administration. 1mg neutralizes ≥100units of heparin; max 50mg/dose.
Avoid rapid administration. Fish allergy. Previous exposure to protamine (including insulin). Severe left ventricular dysfunction. Abnormal pulmonary hemodynamics. Previous vasectomy. Pregnancy (Cat.C). Nursing mothers.
Incompatible with certain antibiotics (eg, cephalosporins, penicillins).
Hypotension, bradycardia, transient flushing, feeling of warmth, dyspnea, GI upset, lassitude, pulmonary edema, anaphylaxis, cardiovascular collapse, pulmonary vasoconstriction, pulmonary hypertension.
Vial (5mL)—25; 25mL—1
Endocrinology Advisor Articles
- Cushing Syndrome Results in Poor Quality of Life Even After Remission
- DPP-4 Inhibitors and Incidence of Rheumatoid Arthritis in Type 2 Diabetes
- Cost-Benefit Analysis of Insulin Analogs in Type 2 Diabetes
- Nonfunctioning Adrenal Incidentaloma Associated With Metabolic Syndrome
- Low Predictive Power of Biomarkers for Estimated Glomerular Filtration Rate Decline
- Nutraceuticals May Benefit Patients Who Are Statin Intolerant
- Link Between Gestational Diabetes and Risk for CVD and Diabetes in Hispanic/Latina Population
- Clinical Characteristics Altering Risks and Benefits of Sulfonylureas and Thiazolidinedione Therapy in T2D
- 6 Factors Related to Inclusion in Health Care Workplace Identified
- Weight Gain After Quitting Smoking May Increase Risk for T2D