PENTAM 300 Rx
Generic Name and Formulations:
Pentamidine isethionate 300mg/vial; lyophilized pwd for IM or IV inj after reconstitution.
Fresenius Kabi USA
Indications for PENTAM 300:
Pneumonia due to Pneumocystis carinii.
Adults and Children:
<4months: not recommended. Give by deep IM or IV inj. If administered by IV, must infused over 60–120 minutes. ≥4months: 4mg/kg once daily for 14–21 days. Therapy >21 days has been used; but may increase toxicity risk.
Hyper- or hypotension. Ventricular tachycardia. Hypo- or hyperglycemia. Hypocalcemia. Pancreatitis. Leukopenia. Thrombocytopenia. Anemia. Hepatic or renal dysfunction. Stevens-Johnson syndrome. Monitor BP, BUN, serum creatinine, blood glucose, CBC and platelets, liver function (eg, serum bilirubin, alkaline phosphatase, AST/ALT), serum calcium, ECG. Avoid extravasation. Have resuscitation equipment available. Pregnancy (Cat.C; avoid). Nursing mothers: not recommended.
Additive effects with concomitant other nephrotoxic drugs (eg, aminoglycosides, amphotericin B, cisplatin, foscarnet, vancomycin); monitor closely or avoid if possible.
Inj site reactions, severe hypotension, hypoglycemia, diabetes, acute pancreatitis, cardiac arrhythmias, nephrotoxic events (eg, renal dysfunction, elevated serum creatinine, azotemia, renal failure), leukopenia, elevated liver functions tests, anorexia/nausea, rash, pruritus.
Endocrinology Advisor Articles
- ACP Defends Higher Blood Glucose Targets for Type 2 Diabetes
- Updated Clinical Practice Guidelines on Testosterone Therapy in Men With Hypogonadism
- Semaglutide May Be Useful for Treating Obesity in People Without Diabetes
- Once-Daily Oral Contraceptive for Men Shows Promise
- HbA1c Levels Affect Serum Phospholipids, Inflammation inT2D, CVD
- American College of Physicians Releases 4 Guidelines for HbA1c Targets in T2D
- Dyslipidemia Drug Indications
- No Difference in Weight Loss Outcomes With Low-Fat vs Low-Carbohydrate Diet
- Damaging Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture
- Gastric Bypass Surgery Linked to Increased Risk for Nonvertebral Fractures
- Common Plant-Derived Oils May Contain Endocrine-Disrupting Chemicals
- Red Meat Consumption Linked to Insulin Resistance and Steatohepatitis
- Effect of High Androgen Levels on Cardiovascular Risk in Postmenopausal Women
- Fertility in Women Negatively Affected by Asthma Medications
- Glucocorticoid Use in COPD Does Not Increase Fracture Risk