Pediatric Endocrinology

ISPAD Issues Consensus Statement on Diabetic Ketoacidosis and Hyperglycemia

ISPAD Issues Consensus Statement on Diabetic Ketoacidosis and Hyperglycemia

By

ISPAD recommends adjustments for fluid management regarding rehydration rates in children and adolescents with diabetes ketoacidosis.

MiniMed 670G System Approved for Use in Younger Patients With T1D

MiniMed 670G System Approved for Use in Younger Patients With T1D

By

The MiniMed 670G system measures glucose levels every 5 minutes and automatically adjusts insulin delivery to avoid highs and lows.

Safety and Performance of Omnipod HCL for Children With Type 1 Diabetes

Safety and Performance of Omnipod HCL for Children With Type 1 Diabetes

By

In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.

Metabolic Health Predicative of Cognitive Development in Children

Metabolic Health Predicative of Cognitive Development in Children

By

Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.

Effect of Infant Feeding Practices and Gut Microbiota on Overweight in First Year

Effect of Infant Feeding Practices and Gut Microbiota on Overweight in First Year

Researchers assessed the effect of formula supplementation vs breastfeeding on the gut microbiome and risk of infant overweight.

Burosumab May Benefit Children With X-Linked Hypophosphatemia

Burosumab May Benefit Children With X-Linked Hypophosphatemia

Subcutaneous burosumab decreases mean Thacher rickets severity total score from dosing every two weeks or every four weeks.

Increased Risk for Type 2 Diabetes in Adolescents, Young Adults With ADHD

Increased Risk for Type 2 Diabetes in Adolescents, Young Adults With ADHD

These findings can inform clinical practice in that type 2 diabetes should be considered in ADHD even in the absence of other known risk factors.

Childhood Overweight Increases Risk for Type 2 Diabetes in Adulthood

Childhood Overweight Increases Risk for Type 2 Diabetes in Adulthood

By

Investigators examined changes in weight from childhood to early adulthood and the risk for developing type 2 diabetes.

Glycemic Control Variations for Children, Adolescents With T1D in High-Income Countries

Glycemic Control Variations for Children, Adolescents With T1D in High-Income Countries

By

Investigators examined glycemic control variations in 8 high-income countries from multicenter registries in children with type 1 diabetes.

Effect of Maternal Caffeine Intake on Childhood Growth

Effect of Maternal Caffeine Intake on Childhood Growth

By

Maternal caffeine intake >200 mg/day during pregnancy was associated with high weight gain velocity beginning from the first months of life and higher BMI throughout childhood.

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

For children and adults with type 1 diabetes, consuming a very low-carbohydrate diet is associated with exceptional glycemic control.

Effects of Maternal Gestational Diabetes on Neonatal Hypoglycemia: Diet vs Insulin Treatment

Effects of Maternal Gestational Diabetes on Neonatal Hypoglycemia: Diet vs Insulin Treatment

By

Routine screening for neonatal hypoglycemia after pregnancies complicated by gestational diabetes (GD) reveals high incidence of both mild and severe hypoglycemia for both diet-controlled and insulin-treated GD and across the full range of birth weight centiles.

Childhood Insulin Resistance Associated With Later Psychosis

Childhood Insulin Resistance Associated With Later Psychosis

By

The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.

Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D

Mitochondrial, Muscle Ultrastructural Abnormalities Observed in Skeletal Muscle of Young Adults With T1D

By

The study highlights mitochondrial and autophagic differences in the muscles of young adults with type 1 diabetes with moderate glycemic control who exceed recommended activity levels.

Risk for Iodine Deficiency and Hypothyroidism High in Children on Parenteral Nutrition

Risk for Iodine Deficiency and Hypothyroidism High in Children on Parenteral Nutrition

By

Study is the first to reveal a higher prevalence of iodine deficiency and hypothyroidism in children receiving chronic parenteral nutrition.

Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy

Risk for Fetal Loss Early in Pregnancy Not Greater With Noninsulin vs Insulin Therapy

By

Compared to standard insulin treatment, noninsulin antidiabetic agents did not present an increased risk for fetal losses or major malformations when used in the first trimester of pregnancy.

Vitamin D Insufficiency Associated With Insulin Resistance Independent of Obesity in Children

Vitamin D Insufficiency Associated With Insulin Resistance Independent of Obesity in Children

By

Further clinical trials are needed to explore the potential beneficial effect of vitamin D supplementation, via fortified foods and/or dietary supplements, on insulin resistance, and possibly on weight management.

Factors Identified to Predict Fatty Liver in Obese Teens

Factors Identified to Predict Fatty Liver in Obese Teens

Ethnicity,race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver.

Young Adults With Type 1 Diabetes Show Muscle Metabolic Deficiencies

Young Adults With Type 1 Diabetes Show Muscle Metabolic Deficiencies

Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle.

Autism Does Not Affect Metabolic Control in Type 1 Diabetes

Autism Does Not Affect Metabolic Control in Type 1 Diabetes

By

Awareness of ASD and its manifestations and comorbidities remain imperative in the treatment of T1D, as both conditions require long-term medical follow-up to continue improving diabetes care and metabolic control outcomes.

Obesity Can Negatively Effect Liver in Children as Young as 8

Obesity Can Negatively Effect Liver in Children as Young as 8

Researchers examined the relationship between early to mid-childhood adiposity measures and mid-childhood alanine aminotransferase levels.

Obesity Risk in Infants Born to Women With Diabetes

Obesity Risk in Infants Born to Women With Diabetes

By

Parents and healthcare workers should carefully consider the risk for obesity in infants born to women with diabetes, especially infants born large for gestational age, and should initiate preventive measures where possible.

Risk Factors for Cardiovascular Disease in Youth With Type 1 Diabetes

Risk Factors for Cardiovascular Disease in Youth With Type 1 Diabetes

By

Early treatment of cardiovascular disease risk factors such as dyslipidemia and hypertension will have long-term benefits with low risk and cost and should be more widely used in pediatric type 1 diabetes care.

Strategies to Prevent Obesity in Children

Strategies to Prevent Obesity in Children

By

Of various interventions used in nonclinical settings for the prevention of childhood overweight and obesity, school-based programs that combine nutrition and exercise and include a home-based component appear to be the most effective approaches.

Risk for Childhood Obesity Increased With Low Maternal Vitamin D Levels

Risk for Childhood Obesity Increased With Low Maternal Vitamin D Levels

By

Researchers evaluated the association between low maternal vitamin D status in early pregnancy and the likelihood of childhood obesity in the offspring.

Bariatric Surgery Underused in Adolescents With Severe Obesity

Bariatric Surgery Underused in Adolescents With Severe Obesity

By

Results comparing the prevalence of obesity amongst adolescents with the rate of bariatric surgeries were presented at ENDO 2018.

MiniMed 670G System Improves Glycemic Outcomes in Children With T1D

MiniMed 670G System Improves Glycemic Outcomes in Children With T1D

By

Research findings indicate improved glycemic outcomes in children with T1D using the MiniMed 670G system, similar to those observed for adolescents and adults.

Incidence of Diabetes Insipidus in Children Following Transsphenoidal Surgery

Incidence of Diabetes Insipidus in Children Following Transsphenoidal Surgery

By

Findings demonstrated a high incidence of sodium alterations in children following transsphenoidal surgery, with a 38% combined incidence of diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion.

Case for Continuous Glucose Monitoring in Youth-Onset Type 2 Diabetes

Case for Continuous Glucose Monitoring in Youth-Onset Type 2 Diabetes

By

An increasing number of studies support the use of continuous glucose monitoring in adult patients with T2D, and the observed benefits are likely to extend to youth with T2D.

Obesity Prevalence Remains Stagnant Among Children

Obesity Prevalence Remains Stagnant Among Children

Researchers used data from the National Health and Nutrition Examination Survey for 1999 to 2016 to update the prevalence data on obesity trends among US children and adolescents age 2 to 19 years.

Sign Up for Free e-Newsletters



CME Focus