Osteoporosis

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

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Statin use is associated with better cortical bone characteristics in older women with osteoporosis, but results are dependent upon the potency of the statins.

Lateral Spine Imaging for Vertebral Fractures May Improve Osteoporosis Detection

Lateral Spine Imaging for Vertebral Fractures May Improve Osteoporosis Detection

The use of lateral spine imaging to detect asymptomatic vertebral fractures in older women may improve osteoporosis identification.

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

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There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

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Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

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Investigators assessed the effectiveness of intravenous ibandronate on bone mineral density in patients with osteoporosis who did not respond to oral bisphosphonates.

Incident Vertebral Fracture Risk in Former, Current Smokers With or Without COPD

Incident Vertebral Fracture Risk in Former, Current Smokers With or Without COPD

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Bone attenuation was found to be an independent determinant for vertebral fractures in former smokers with and without chronic obstructive pulmonary disease.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

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A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

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Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.

Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic Screening May Predict Osteoporosis, Fracture Risk

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Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

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Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

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Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

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A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

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Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

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Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

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Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.

Romosozumab: Effective in Men With Osteoporosis

Romosozumab: Effective in Men With Osteoporosis

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Romosozumab increased spine and hip bone mineral density after 12 months of treatment.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening with bone measurement is recommended for women. Younger women are at more risk.

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

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High levels of serotonin are predictive of an increased risk for hip fracture, nonvertebral osteoporotic fracture, and incident fractures in older men.

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

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Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

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Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

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Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

USPSTF Issues Recommendation for Vitamin D, Calcium Supplementation for Fracture Prevention

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The USPSTF has released recommendations for vitamin D and calcium supplementation for the primary prevention of fractures in community-dwelling adults.

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

Greater Bone Formation With Teriparatide vs Zoledronic Acid in Osteoporosis

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Researchers have determined that treatment for osteoporosis with teriparatide is associated with greater bone formation than treatment with zoledronic acid.

Low Sperm Count Linked to Poor Metabolic, Cardiovascular, Bone Health

Low Sperm Count Linked to Poor Metabolic, Cardiovascular, Bone Health

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Researchers tested whether semen quality and reproductive function could be a marker of general health in men.

Gastric Bypass Surgery Linked to Increased Risk for Nonvertebral Fractures

Gastric Bypass Surgery Linked to Increased Risk for Nonvertebral Fractures

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Roux-en Y gastric bypass increased the likelihood of nonvertebral fractures, including hip, wrist, and pelvic fractures.

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

Effect of Growth Hormone Treatment on BMD in Adults With Prader-Willi Syndrome

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Researchers investigated the effects of growth hormone vs placebo, as well as the effects of sex steroid replacement therapy on bone mineral density in growth hormone-treated young adults with Prader-Willi syndrome who had attained adult height.

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

Osteoporotic Fracture Risk Predicted by Vertebral Trabecular Attenuation on Routine CT

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Researchers showed that decreased L1 trabecular attenuation is associated with increased risk for future osteoporotic fractures in adult patients aged ≥65 years undergoing abdominopelvic CT scans for other indications.

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

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In postmenopausal women at high risk for fracture, treatment with romosozumab for 12 months, followed by alendronate, was associated with significantly fewer hip fractures than treatment with alendronate alone.

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

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A recent literature review and meta-analysis indicates that growth hormone therapy may reduce the risk for fracture in patients with osteoporosis.

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

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Teriparatide is associated with a lower risk for new vertebral and clinical fractures compared with risedronate in post-menopausal women being treated for severe osteoporosis.

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