Adiposity Affected by Interaction of Certain Genotypes and Diet
Certain genotypes may interact with dietary intake, thereby affecting central adiposity and body fat composition.
HealthDay News -- Fibroblast growth factor 21 (FGF21) genotypes may interact with dietary macronutrient intake to affect central adiposity and body fat composition, according to a study published in Diabetes Care.
Yoriko Heianza, from Tulane University in New Orleans, and colleagues genotyped FGF21 rs838147 in 715 overweight or obese individuals who were assigned to 1 of 4 diets with varied macronutrient contents.
The researchers observed a significant interaction between FGF21 genotype and carbohydrate/fat intake on 2-year changes in waist circumference (P=.049), as well as percentage of fat mass and trunk fat (P=.001 and .003, respectively).
Carrying the carbohydrate intake-decreasing C allele of rs838147 was marginally associated with less reduction in waist circumference in response to the low-carbohydrate/high-fat diet (P=.08), and was significantly associated with less reduction of total fat mass and trunk fat (P=.01 and .02, respectively).
Among the high-carbohydrate/low-fat diet group, opposite genetic associations with these outcomes were observed; carrying the C allele correlated with a greater reduction in waist circumference, total body fat mass, and trunk fat.
"A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity," the researchers wrote.