Nonalcoholic Fatty Liver Disease
A range of pharmacologic agents have a potential role in the management of NAFLD.
For patients with nonalcoholic fatty liver disease and underlying metabolic disorders, physical activity is associated with a reduction in intrahepatic lipid content and markers of hepatocellular injury.
Clinicians must be aware of the overlap between nonalcoholic fatty liver disease and nonalcoholic steatohepatitis and other metabolic disorders.
Lower thyroid function was associated with a 1.24-fold higher risk for nonalcoholic fatty liver disease.
Treatment with saroglitazar was linked to sonographic improvement in fatty liver.
Duration of estrogen deficiency in women with nonalcoholic fatty liver disease may be more likely to have severe fibrosis.
Researchers found better diagnostic performance for MRI- vs transient elastography-based measurements for liver fibrosis and steatosis.
For obese patients with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is associated with an unfavorable metabolic profile.
Patients with moderate to severe fatty liver disease may be more likely to have impaired myocardial perfusion.
Differences in hepatic fat oxidation may explain higher prevalence, risk for nonalcoholic fatty liver disease in men.
In randomized trial, there was no difference in efficacy of liver fat reduction by aerobic exercise dose or intensity.
Exposure to low doses of hormone-disrupting chemicals may alter the liver genome and function, thereby increasing susceptibility to obesity.
Restricting intake of fructose may prevent accumulation of fat in the liver of obese children.
New imaging techniques show promise for diagnosing NAFLD.
MRI-based technique may aid in detection, evaluation of the disease.
Adiposity at age 3 years linked to diagnosis and severity of hepatic steatosis in late adolescence.
Patients with type 1 diabetes may be less likely to develop fatty liver disease.
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