Neuroendocrinology

Hyperprolactinemia and Insulin Resistance Associated With First-Episode Psychosis

Hyperprolactinemia and Insulin Resistance Associated With First-Episode Psychosis

By

There was a significantly higher level of prolactin found in the first episode psychosis group than in the clinical high risk group, suggesting a condition of hyperprolactinemia.

Guidelines for Management of Hypothalamic-Pituitary, Growth Disorders in Childhood Cancer Survivors

Guidelines for Management of Hypothalamic-Pituitary, Growth Disorders in Childhood Cancer Survivors

By

The Endocrine Society, European Society of Endocrinology, and Pediatric Endocrine Society issue guidelines for the management of hypothalamic-pituitary and growth disorders in childhood cancer survivors.

Metabolic Syndrome Linked to Reduced Neurocognitive Function in Midlife

Metabolic Syndrome Linked to Reduced Neurocognitive Function in Midlife

By

Researchers found that metabolic syndrome was associated with lower neurocognitive function, particularly among middle-aged adults.

Later Natural Menopause Can Benefit Future Verbal Memory

Later Natural Menopause Can Benefit Future Verbal Memory

Women who have a later natural menopause maintain a small benefit in verbal memory compared with women with earlier menopause.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in T1D vs T2D

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in T1D vs T2D

By

The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

Altered Neural Responses in Memory Processing With Type 1 Diabetes

Altered Neural Responses in Memory Processing With Type 1 Diabetes

Young adults with type 1 diabetes have altered neural responses during working memory processing.

Evidence of Impaired Glucose Signaling in Amyotrophic Lateral Sclerosis

Evidence of Impaired Glucose Signaling in Amyotrophic Lateral Sclerosis

By

Further research is warranted to clarify the role played by insulin resistance in the pathogenesis of amyotrophic lateral sclerosis.

Risk Factors for Developing Diabetic Polyneuropathy in Type 2 Diabetes

Risk Factors for Developing Diabetic Polyneuropathy in Type 2 Diabetes

By

Study provides stronger epidemiological evidence for obesity as a risk factor for diabetic polyneuropathy.

Hormone Therapy May Impact Brain Structure, Cognition

Hormone Therapy May Impact Brain Structure, Cognition

Researchers assessed the effects of 2 frequently used formulations of menopausal hormone therapy on brain structure and cognition 3 years after the completion of a randomized clinical trial.

Retinopathy May Accelerate Rates of Cognitive Decline

Retinopathy May Accelerate Rates of Cognitive Decline

Researchers assessed whether retinal vascular signs were associated with greater cognitive decline over 20 years.

Differential Changes in Total Testosterone Levels Found in Schizophrenia

Differential Changes in Total Testosterone Levels Found in Schizophrenia

Testosterone levels were increased in women with stable multi-episode schizophrenia and decreased in men with stable multi-episode schizophrenia.

Vitamin E Ineffective in Diabetic Peripheral Neuropathy-Associated Symptoms

Vitamin E Ineffective in Diabetic Peripheral Neuropathy-Associated Symptoms

By

Oral vitamin E supplementation consisting of 400 mg/day mixed tocotrienols for 1 year may not result in improved neuropathic pain symptoms in patients with diabetic peripheral neuropathy.

HbA1c Levels Associated With Long-Term Cognitive Decline in Diabetes

HbA1c Levels Associated With Long-Term Cognitive Decline in Diabetes

By

A recent study assessed the affiliation between HbA1c level, diabetes prominence, and successive decline of cognition during a 10-year span.

FDA Accepts New Drug Application for Treatment of Rare Neuroendocrine Tumors

FDA Accepts New Drug Application for Treatment of Rare Neuroendocrine Tumors

By

The Food and Drug Administration has accepted the New Drug Application for Azedra for the treatment of malignant, recurrent and/or unresectable pheochromocytoma and paraganglioma.

Migraine Management in Female Reproduction

Migraine Management in Female Reproduction

By

The relationship between hormones and migraine is most frequently pronounced during the female reproductive years.

Early-Day Psychotherapy Enhanced by Higher Cortisol Levels

Early-Day Psychotherapy Enhanced by Higher Cortisol Levels

For patients with panic disorder with agoraphobia, cortisol mediates the effect of the time of day on subsequent outcome.

Aldosterone Reduced With Losartan in Hypertension Without Obstructive Sleep Apnea

Aldosterone Reduced With Losartan in Hypertension Without Obstructive Sleep Apnea

For patients with hypertension and obstructive sleep apnea, treatment with losartan does not lead to significant reductions in aldosterone, but the treatment is tied to aldosterone reductions in patients with hypertension but without obstructive sleep apnea.

Researchers Find Sex-Specific Role for Glucokinase in Autonomic Nervous Activity

Researchers Find Sex-Specific Role for Glucokinase in Autonomic Nervous Activity

An experimental study found a sex-specific role in glucose-dependent control of autonomic nervous activity.

Type 2 Diabetes May Affect Brain Gray Matter Volume in Youths

Type 2 Diabetes May Affect Brain Gray Matter Volume in Youths

By

Younger patients with type 2 diabetes had significant differences in brain gray matter volume compared with healthy controls.

Striatal D2 Receptors, Age Associated With Sucrose Preference

Striatal D2 Receptors, Age Associated With Sucrose Preference

For participants without obesity, striatal D2 receptor (D2R) binding potential and age are associated with sucrose preference.

Gastric Bypass Reduces Symptoms, Hormonal Responses to Hypoglycemia

Gastric Bypass Reduces Symptoms, Hormonal Responses to Hypoglycemia

Gastric bypass surgery is associated with reduced symptoms and neurohormonal responses to hypoglycemia, according to a study published in Diabetes.

Late Luteal Phase Estrogen Levels Dropped More Rapidly in Women With Migraine

Late Luteal Phase Estrogen Levels Dropped More Rapidly in Women With Migraine

By

The findings suggest a neuroendocrine vulnerability in women with migraine.

New Instrument Measuring Treatment Satisfaction May Benefit Patients With Acromegaly

New Instrument Measuring Treatment Satisfaction May Benefit Patients With Acromegaly

By

A new instrument may provide physicians insight into satisfaction with acromegaly treatment.

Hormone Insufficiencies May Be Prevalent After Blast Concussion in Veterans

Hormone Insufficiencies May Be Prevalent After Blast Concussion in Veterans

By

Chronic hypopituitarism was noted in 44% of US veterans with mild traumatic brain injury.

Plasticizers in Medical Tubes Linked to Attention Deficit In Children

Plasticizers in Medical Tubes Linked to Attention Deficit In Children

By

Phthalate exposure effect explained half of the attention deficit in children treated in the ICU.

Acromegaly Diagnosis Delayed in Elderly Woman

Acromegaly Diagnosis Delayed in Elderly Woman

The presence of a pituitary tumor on magnetic resonance imaging confirmed the diagnostic hypothesis.

Pioglitazone May Mitigate Depressive Symptoms in Patients with Insulin Resistance

Pioglitazone May Mitigate Depressive Symptoms in Patients with Insulin Resistance

Insulin resistance may underlie some cases, researchers said.

Two Genes May Alter Brain Responses to High-Calorie Foods

Two Genes May Alter Brain Responses to High-Calorie Foods

By

Two genetic variants are associated with heightened brain reward responses to foods high in fat and sugar.

Hypothalamic Gliosis May Be Associated With Insulin Resistance, Obesity

Hypothalamic Gliosis May Be Associated With Insulin Resistance, Obesity

By

New data link hypothalamic gliosis with higher BMI and increased insulin resistance.

Transcranial Direct Current Stimulation May Help Curb Overeating

Transcranial Direct Current Stimulation May Help Curb Overeating

By

Noninvasive brain stimulation may help decrease caloric intake and promote weight loss.

Sign Up for Free e-Newsletters



CME Focus