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MAGNEVIST
Imaging agents
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Drug Name:

MAGNEVIST Rx

Generic Name and Formulations:
Gadopentetate dimeglumine 469.01mg/mL (0.5mmol/mL); soln for IV inj; preservative-free.

Company:
Bayer Healthcare Pharmaceuticals Inc.

Therapeutic Use:

Indications for MAGNEVIST:

For use in MRI of the brain (intracranial lesions), spine and associated tissues, of the head and neck, and of the body (excluding the heart) in adults and children to visualize lesions with abnormal vascularity.

Adults and Children:

<2yrs: not established. Give by IV inj at a rate of max 10mL/15secs. ≥2yrs: 0.2mL/kg (0.1mmol/kg), followed by 5mL normal saline flush to ensure complete injection. >286lbs: dose not established.

Contraindications:

Chronic, severe kidney disease (GFR<30mL/min/1.73m2). Acute kidney injury.

Boxed Warning:

Nephrogenic systemic fibrosis.

Warnings/Precautions:

Increased risk of nephrogenic systemic fibrosis in chronic kidney disease or acute kidney injury (see Contraindications). Screen for renal dysfunction. Do not exceed recommended dose and allow sufficient time for drug elimination before re-administration. Have emergency resuscitative equipment available. History of asthma or other allergic disorders. Monitor for signs/symptoms of hypersensitivity reactions during and up to several hrs after administration. Increased risk of gadolinium retention with multiple lifetime doses, in pregnant patients, children, and those with inflammatory conditions; minimize repetitive imaging studies. Renal impairment: use lowest effective dose. Avoid extravasation. Interpreting Magnevist MRI scans without a companion non-contrast MRI. Elderly. Pregnancy. Nursing mothers.

Pharmacological Class:

Gadolinium-based contrast agent.

Adverse Reactions:

Headache, nausea, inj site coldness/localized coldness, dizziness; hypersensitivity reactions; rare: inj site reactions.

How Supplied:

Single-dose vials (5mL, 10mL, 15mL, 20mL)—20; Pre-filled syringes (10mL, 15mL, 20mL)—5

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