Lipids and Cholesterol

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Elevated Triglycerides, Diabetes May Be Predictors Major Cardiovascular Events

Elevated Triglycerides, Diabetes May Be Predictors Major Cardiovascular Events

Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.

Fenofibrate Improves Cholesterol Levels in Type 2 Diabetes

Fenofibrate Improves Cholesterol Levels in Type 2 Diabetes

To understand the mechanism underlying the benefit of fenofibrate on vascular complications in patients with type 2 diabetes, investigators assessed carotid intima thickness as a marker of subclinical atherosclerosis.

Depression, C-Reactive Protein, and Osteoprotegerin May Affect Dyslipidemia

Depression, C-Reactive Protein, and Osteoprotegerin May Affect Dyslipidemia

Investigators sought to determine whether serum lipid levels were associated with depression in patients with psychotic disorders.

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Using both public and private health insurance claims data, investigators conducted a retrospective cohort study to assess cardiovascular risk in the setting of diabetes and rheumatoid arthritis.

No Cardiovascular Benefit With Fenofibrate in T2D and Hypertriglyceridemia

No Cardiovascular Benefit With Fenofibrate in T2D and Hypertriglyceridemia

Statins were associated with a reduction in mortality but there was no significant difference in the composite end point with fenofibrates alone or in combination with statins.

Effect of Fenofibrate Varies Widely in Type 2 Diabetes

Effect of Fenofibrate Varies Widely in Type 2 Diabetes

The method of individualized treatment effect prediction of fenofibrate on major cardiovascular events risk reduction in T2D can be used to guide clinical decision-making.

Lipid Metabolism Imbalance and Pathophysiology of Bipolar Disease

Lipid Metabolism Imbalance and Pathophysiology of Bipolar Disease

Abnormal ratios of omega-6 to omega-3 fatty acids were associated with the presence of bipolar disorder and the severity and duration of major depressive disorder.

Statins Beneficial for High-Risk Patients Despite Adverse Reactions

Statins Beneficial for High-Risk Patients Despite Adverse Reactions

From 25% to 50% of patients discontinue statins within 6 months to 1 year of starting, and the rate increases as high as 75% after 2 years.

FDA Approves Pitavastatin for Hyperlipidemia, Mixed Dyslipidemia

FDA Approves Pitavastatin for Hyperlipidemia, Mixed Dyslipidemia

Multiple clinical studies have examined the efficacy of pitavastatin.

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