The U.S. Food and Drug Administration is implementing a number of steps for long-term safety monitoring of the permanent birth control device Essure, which will no longer be sold or distributed in the United States after Dec. 31, 2018.
Postmenopausal women with edentulism are at an increased risk for developing hypertension.
Intimate partner violence, sexual assault, and symptoms of posttraumatic stress disorder may be associated with menopause symptoms.
Almost two-thirds of U.S. women aged 15 to 49 years were currently using contraception in 2015 to 2017.
Providers should maximize women's health during the interpregnancy period, continuing care beyond the immediate postpartum period.
Men who use androgenic anabolic steroids have an increased mortality risk, a notable increase in hospitalizations, and higher prevalence of certain disorders compared with the general population.
A longer duration of infertility was associated with lower sperm concentrations and higher rates of azoospermia in men with primary infertility.
A high BMI is associated with reduced follicle-stimulating hormone receptor expression in human chorionic gonadotropins, reduced expression of estradiol synthesis-related genes, and reduced production of estradiol.
Fetal exposure to famine is associated with an increased risk for early menopause.
Oxybutynin, an anticholinergic used to treat urinary incontinence, may provide breast cancer survivors with an alternative treatment option for hot flashes, according to new research.
Phase 3 trial results assessing the intrauterine system, Liletta (levonorgestrel 52 mg), found that it had >99% efficacy in preventing pregnancy for up to 5 years; the products current Food and Drug Administration indication.
Exposure to certain endocrine disrupting chemicals may impact timing of puberty in children.
To investigate the association between hormone therapy and carpal tunnel syndrome risk, researchers conducted a secondary analysis of the Women's Health Initiative (WHI) hormone therapy trials.
Severe vulvovaginal atrophy (VVA) symptoms are associated with worse quality of life in postmenopausal women.
Drospirenone is a spironolactone analogue with antimineralocorticoid and antiandrogenic activity.
Women who undergo surgical menopause have significantly worse sleep quality than those who experience natural menopause.
Prior to starting Xyosted, the patient's baseline cardiovascular risk should be considered and blood pressure should be adequately controlled.
The year-long Phase 2b trial, funded by the National Institutes of Health, will enroll approximately 420 couples that are seeking pregnancy prevention across 3 US sites (Los Angeles, Seattle, and Kansas City).
In a select sample of men, testosterone treatment in higher doses was observed to be effective for reducing depressive symptoms.
In older men with low testosterone concentrations, testosterone therapy improves self-reported walking ability and outcomes on the 6-minute walking test.
In addition to the risk that children with CPP will not reach their adult height potential, a range of studies have noted a high risk for psychological, social, and behavioral problems in this population.
Functional disability progressed more rapidly in postmenopausal compared with premenopausal women with rheumatoid arthritis.
Without proper instructions for the correct use of the Veridate dispenser pack, the patient may take the pills in the wrong order or may take an inactive "reminder" pill vs an "active" pill.
Women entering menopause had patterns of cardiometabolic risk components related to race/ethnicity.
Approximately 15% of men experiencing infertility may have undiagnosed prediabetes.
Approval from the Food and Drug Administration (FDA) was supported by the Phase 3 Replenish trial which evaluated the safety and efficacy of Bijuva in generally healthy, postmenopausal women with a uterus for the treatment of moderate to severe hot flashes.
Compared with women who experience normal or late menopause, women who experience early natural menopause have a shorter life expectancy and spend fewer years without type 2 diabetes.
The Endocrine Society has expressed concern regarding the FDA's position on use of BPA in commercial products.
Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.
During 2007 to 2017, fertility rates decreased in the United States for each urbanization level.
Middle-aged testosterone replacement therapy users with COPD had a greater reduction in hospitalizations compared with nonusers.
The expanded approval was supposed by safety and efficacy data from the Phase 3 ACCESS IUS trial (N = 1751) in women receiving Liletta. In the trial, Liletta demonstrated >99% efficacy in preventing pregnancy for up to 5 years in a broad patient population.
Daily oral administration of dimethandrolone undecanoate for 28 days in healthy men is well tolerated and has properties consistent with an effective male contraceptive.
Postmenopausal women with weight loss have a reduced risk for breast cancer.
Paying a surrogate to carry a fetus shoehorns a fourth, and fifth, party into the already tight therapeutic triangle formed by the biological mom, fetus, and physician.
Xyosted carries a Boxed Warning regarding blood pressure increases that may potentially increase the risk for major adverse cardiovascular events.
Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.
One-third of the women enrolled in Michigan's Medicaid expansion program reported improved access to birth control and family planning services.
These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.
Researchers concluded that physical activity was not associated with risk for early menopause.
Healthy nonmenopausal women taking oral contraceptives exhibited biomarkers for drug-induced torsade de pointes.
High-quality health care needs to be provided to lesbian, gay, bisexual, transgender, and queer (LGBTQ) patients, and improved training is necessary to deliver that care.
Issues to consider include how to address patients, obtaining inclusive history, and unique clinical challenges.
The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).
While it is now well-established that having MS should not limit patients' reproductive choices, this was not always the case.
Investigators assessed whether adrenal suppression with low-dose dexamethasone improved IVF outcomes.
Investigators sought to determine the effect of vitamin D deficiency on the success of ovarian stimulation in women with PCOS or unexplained infertility.
Investigators examine total testosterone, free testosterone, and sex hormone binding globulin levels in pregnant women in the third trimester with PCOS.
For this study, researchers investigated the incidence of primary ovarian insufficiency incidence and estimated risk for POI after vaccination with human papillomavirus, Tdap, influenza and meningococcal conjugate using Kaiser Permanente Northwest electronic health records from 2006 to 2014.
This finding suggests that clinicians should monitor anxiety among individuals with testosterone deficiency and XXY.
Investigators examined the relationship between menstrual cycle characteristics in adolescence and early adulthood and the risk for early natural menopause.
Cytovene-IV is a deoxynucleoside analogue cytomegalovirus (CMV) DNA polymerase inhibitor.
The American Medical Association strongly objects to the Trump administration's plan to withhold federal family planning funding from Planned Parenthood and other entities.
Adolescent and young adult cancer survivors have a 73 percent higher risk of endocrine diseases.
The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.
Amid lawsuits and plummeting sales for its Essure birth control device, Bayer announced Friday that it would cease U.S. sales of the product by the end of 2018.
Investigators examine the onset of puberty and testicular function in prepubertal boys treated with oxandrolone.
No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms
Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.
Equol-containing nutraceuticals may be beneficial for postmenopausal women with vaginal symptoms.
In 2014, the US Food and Drug Administration issued a safety bulletin for the use of testosterone.
Investigators aimed to determine the prevalence of fatigue in women diagnosed with endometriosis.
Investigators aimed to determine the level of midluteal progesterone associated with low probability of live birth following intrauterine insemination.
Only half of patients with initial treatment success maintain benefits at two years.
Symptoms more likely in those reporting fair health, history of non-spontaneous menopause
Menopausal hormone therapy may slow cognitive decline in postmenopausal women with mild cognitive impairment.
Researchers sought to determine whether the reduced mortality seen in women receiving reproductive assistance occurred as a result of improved general health in this population.
These analyses may serve clinicians in addressing potential psychiatric obstacles in patients undergoing fertility treatments.
Researchers assessed the effect of testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin levels on coronary heart disease, heart failure, and cardiovascular disease in postmenopausal women.
The case study focused on the story of a clinician who arrived in Lebanon to discuss how to best offer infertility treatment to Syrian refugees in the region.
To evaluate safety and efficacy of this therapy, study authors gathered data on patients treated with the combination from 2014 to 2017.
Investigators examined the effect of testosterone replacement therapy on metabolic syndrome and vascular function in obese males with hypogonadism.
Men with higher estradiol and estradiol/testosterone levels had an increased risk for pulmonary arterial hypertension.
Physical activity modifies the association between the body mass index genetic risk score and BMI.
Serum chemerin may serve as a biomarker to identify pregnant women with polycystic ovary syndrome who are at particular risk for later abortion, and who may benefit from prevention strategies.
Meta-analysis shows that alcohol intake is moderately associated with premenstrual syndrome risk.
Recognizing the increased need for antibiotic stewardship, the researchers consider HAAT to be a useful alternative to systemic antibiotic therapy that is effective and well tolerated among women with inflammatory acne.
Metformin treatment during pregnancy did not influence the metabolic profile in women with polycystic ovary syndrome at 7.7 years of follow-up.
Menstrual dysfunction is common in girls with recently diagnosed type 2 diabetes, and does not improve with 2years of anti-hyperglycemic treatment.
These data confirmed the increased risk for psychiatric disorders in women with PCOS, and indicated an increased risk for ADHD and ASD in their children.
Clinicians should use a total testosterone level below 300ng/dL as a reasonable cut-off in support of the diagnosis of low testosterone.
Researchers evaluated the association between PCOS and psychiatric outcomes, as well as whether rates of autism spectrum disorder and attention-deficit/hyperactivity disorder are higher in children of mothers with PCOS.
Results from the ongoing Platinum Study revealed the prevalence of risk factors for CVD among survivors of testicular cancer who received chemotherapy for their cancer.
A number of adverse events or side effects have been reported, but this is the first report of hyperprolactinemia as the result of ingestion of kratom.
Bremelanotide, an investigational product, is thought to possess a novel mechanism of action, activating endogenous melanocortin pathways involved in sexual desire and response.
Researchers conducted a prospective, population-based cohort study to assess the risk for cardiovascular disease in postmenopausal women with increased androgen levels.
The management of asthma with short-acting beta-agonists was associated with reduced fertility rates in women, whereas treatment with inhaled corticosteroids or long-acting beta-agonists was not.
Testosterone therapy is recommended in men with hypogonadism to correct symptoms of testosterone deficiency. Men who are otherwise healthy do not need to be screened for hypogonadism.
Karyotyping of girls with short stature and high FSH levels would allow early diagnosis of Turner syndrome in a significant number of patients, especially where resources for chromosome study are limited.
A new birth control pill for men appears to be safe when used daily for a month, with hormone responses consistent with effective contraception.
Researchers tested whether semen quality and reproductive function could be a marker of general health in men.
A new study presented at ENDO 2018 finds that giving 1 year of estrogen replacement to female athletes with exercise-induced menstrual irregularities improves drive for thinness, body dissatisfaction, and uncontrolled eating.
Testosterone levels were increased in women with stable multi-episode schizophrenia and decreased in men with stable multi-episode schizophrenia.
Researchers examined the correlation between Cobb angle of kyphosis from lateral spine radiographs and pattern of self-reported menopausal hormone therapy use.
Variable improvements in menses, hormones, and metabolism were seen during 24 months of metformin use in 119 women with PCOS sub-grouped by baseline weight and androgen status.
Study evaluated the difference in the rate of ongoing pregnancy or live birth between frozen embryo transfer and fresh embryo transfer in women without polycystic ovary syndrome who were undergoing IVF.
The FDA has approved Zomacton, a somatropin injection, for the replacement of growth hormone in adults with GH deficiency.
Exposure to air pollution during high school is associated with a slightly higher likelihood of menstrual irregularity and longer time to regularity.
Medicaid policy encourages the use of long-acting reversible contraception, but state-level payment policies are inconsistent and often do not include critical aspects of care.
Researchers have found that lower alpha diversity is seen in women with polycystic ovary syndrome vs healthy women.
Women with migraine with aura are at an increased risk for stroke if they are taking high-dose estrogen-containing contraceptives.
Endocrinology Advisor Articles
- Testosterone Use Remains High Among Men With Coronary Artery Disease
- Insulin Analogs vs Regular Human Insulin for Type 2 Diabetes
- Primary Characteristics of PCOS Predictive of Obstetric Complications
- Trends in Bisphosphonate Use and Hip Fracture Rates in Denmark
- Maternal Thyroid Function in Pregnancy Linked to Childhood Risk for Disease
- ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care
- Sleep Habits Affect Insulin Sensitivity in Adolescents With Overweight, Obesity
- Levothyroxine Associated With Increased Mortality in Patients With Heart Failure
- Head-to-Head Comparison of Professional vs Personal CGM Systems in T1D
- Dual vs Triple Therapy for Metformin Treatment Intensification in Type 2 Diabetes
- Risk for Congenital Heart Defects in Offspring of Mothers With Obesity
- Is the MiniMed 670G System Safe for Children With Type 1 Diabetes?
- Gender-Affirming Hormonal Treatment and Long-Term Bone Safety
- Obesity Linked to Lower Gray Matter Brain Volume
- No Evidence for Health Benefits of Nonsugar Sweeteners