Hyperlipidemia

Characteristics of Acquired Partial Lipodystrophy With Metabolic Abnormalities

Characteristics of Acquired Partial Lipodystrophy With Metabolic Abnormalities

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Investigators analyze characteristics of participants with acquired partial lipodystrophy who developed severe metabolic abnormalities.

Genetic Testing Recommended for Familial Hypercholesterolemia

Genetic Testing Recommended for Familial Hypercholesterolemia

Genetic testing should become the standard of care for patients with definite or probable familial hypercholesterolemia.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

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A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

High LDL in Young, Healthy Adults Leaves Them Vulnerable to CVD

High LDL in Young, Healthy Adults Leaves Them Vulnerable to CVD

Low-density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) ≥160 mg/dL are independently associated with increased relative risk of cardiovascular disease (CVD) mortality in a low-risk cohort.

Akcea and Ionis Receive Complete Response Letter for WAYLIVRA from FDA

Akcea and Ionis Receive Complete Response Letter for WAYLIVRA from FDA

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"We are extremely disappointed with the FDA's decision. We continue to feel strongly that Waylivra demonstrates a favorable benefit/risk profile in people with FCS," said Akcea CEO, Paula Soteropoulos.

Vitamin D Independently, Inversely Tied to Total, HDL, LDL Cholesterol in Children

Vitamin D Independently, Inversely Tied to Total, HDL, LDL Cholesterol in Children

Serum 25-hydroxyvitamin D [25(OH)D] is independently and inversely associated with total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol in children.

Nutraceuticals May Benefit Patients Who Are Statin Intolerant

Nutraceuticals May Benefit Patients Who Are Statin Intolerant

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Nutraceuticals may offer a solution to patients who cannot tolerate statins because of severe muscle pain.

CDC: More People With High Cholesterol Taking Medications

CDC: More People With High Cholesterol Taking Medications

There has been a substantial increase in the percentage of patients with high cholesterol over age 60 years taking lipid-lowering medications from 2005 to 2016, but such increases have not been seen among younger patients with high cholesterol.

Revised Pooled Cohort Equations for CVD Risk Improve Accuracy of Estimates

Revised Pooled Cohort Equations for CVD Risk Improve Accuracy of Estimates

Investigators revised pooled cohort equations to improve clinical accuracy to predict risk for cardiovascular disease.

Cardiovascular Outcomes in Patients With ACS, Diabetes Using Alirocumab

Cardiovascular Outcomes in Patients With ACS, Diabetes Using Alirocumab

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Investigators examine the effects of the PCSK9 inhibitor alirocumab in patients with recent acute coronary syndrome and diabetes.

Elevated Triglycerides, Diabetes May Be Predictors of Major Cardiovascular Events

Elevated Triglycerides, Diabetes May Be Predictors of Major Cardiovascular Events

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Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

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For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Rheumatoid Arthritis Not as Likely to Increase CVD Risk as Diabetes

Using both public and private health insurance claims data, investigators conducted a retrospective cohort study to assess cardiovascular risk in the setting of diabetes and rheumatoid arthritis.

Statins Beneficial for High-Risk Patients Despite Adverse Reactions

Statins Beneficial for High-Risk Patients Despite Adverse Reactions

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From 25% to 50% of patients discontinue statins within 6 months to 1 year of starting, and the rate increases as high as 75% after 2 years.

FDA Approves Pitavastatin for Hyperlipidemia, Mixed Dyslipidemia

FDA Approves Pitavastatin for Hyperlipidemia, Mixed Dyslipidemia

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Multiple clinical studies have examined the efficacy of pitavastatin.

Hydroxychloroquine May Lower Hyperlipidemia Risk in Early Rheumatoid Arthritis

Hydroxychloroquine May Lower Hyperlipidemia Risk in Early Rheumatoid Arthritis

Reduced risk for hyperlipidemia with hydroxychloroquine vs. other disease-modifying antirheumatic drugs.

Fenofibrate May Mimic Cannabinoid Receptor Stimulation

Fenofibrate May Mimic Cannabinoid Receptor Stimulation

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Researchers have discovered that a common medication indicated for the treatment of high cholesterol may stimulate the same peroxisome proliferator-activated receptors (PPARs) as cannabinoids, which could lead to a new class of cannabis-like drugs to treat a range of conditions.

High Cholesterol in Young Adulthood Heightens CHD Risk

High Cholesterol in Young Adulthood Heightens CHD Risk

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Young adults with high cholesterol have an increased risk for developing coronary heart disease later in life.

Nurse-Managed Protocols Improved Outpatient Care in Chronic Illnesses

Nurse-Managed Protocols Improved Outpatient Care in Chronic Illnesses

Outcomes positive for nurse-managed protocols in patients with chronic conditions.

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