(HealthDay News) — Vitamin D supplementation is not associated with a reduction in blood pressure (BP), according to a systematic review and meta-analysis published in JAMA Internal Medicine.
Louise A. Beveridge, MB, ChB, from the University of Dundee in the United Kingdom, and colleagues conducted a systematic review to examine whether supplementation with vitamin D or vitamin D analogues reduced BP. Data were included from 46 trials with 4,541 participants in a trial-level meta-analysis. Individual patient data were included for 3,092 participants in 27 trials.
The researchers found that vitamin D supplementation had no effect on systolic BP (effect size, 0.0 mm Hg; P=.97) or diastolic BP (effect size, –0.1 mm Hg; P=.84) at the trial level. Similar results were seen on analysis of individual patient data (systolic BP: effect size, –0.5; P=.27; diastolic BP: effect size, 0.2; P=.38).
No baseline factor was found to predict a better response to therapy in subgroup analysis.
“Vitamin D supplementation is ineffective as an agent for lowering blood pressure and thus should not be used as an antihypertensive agent,” the researchers wrote.