(HealthDay News) — Vitamin D supplementation is not associated with a reduction in blood pressure (BP), according to a systematic review and meta-analysis published in JAMA Internal Medicine.

Louise A. Beveridge, MB, ChB, from the University of Dundee in the United Kingdom, and colleagues conducted a systematic review to examine whether supplementation with vitamin D or vitamin D analogues reduced BP. Data were included from 46 trials with 4,541 participants in a trial-level meta-analysis. Individual patient data were included for 3,092 participants in 27 trials.

The researchers found that vitamin D supplementation had no effect on systolic BP (effect size, 0.0 mm Hg; P=.97) or diastolic BP (effect size, –0.1 mm Hg; P=.84) at the trial level. Similar results were seen on analysis of individual patient data (systolic BP: effect size, –0.5; P=.27; diastolic BP: effect size, 0.2; P=.38). 

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No baseline factor was found to predict a better response to therapy in subgroup analysis.

“Vitamin D supplementation is ineffective as an agent for lowering blood pressure and thus should not be used as an antihypertensive agent,” the researchers wrote.


  1. Beveridge LA et al. JAMA Intern Med. 2015;doi:10.1001/jamainternmed.2015.0237.