Intensified, Multifactorial Intervention for Type 2 Diabetes Reduces Risk for Heart Failure

chest xray heart failure
chest xray heart failure
Investigators examined the effect of intensified multifactorial intervention on the risk for heart failure-related hospitalization in patients with type 2 diabetes and microalbuminuria.

For patients with type 2 diabetes, intensified, multifactorial intervention can reduce the risk for heart failure by 70%, according to results published in Diabetologia.

According to these results, clinicians should recommend an intensified multifactorial intervention for patients with type 2 diabetes to reduce the risk for heart failure.

The study included participants with type 2 diabetes who were randomly assigned to conventional or intensified multifactorial intervention (n=160). In the conventional group, participants followed national recommendations at all times (n=80). In the intensive group, participants had stricter glycemic, lipid, and blood pressure targets, and participants received angiotensin-converting enzyme inhibitors and aspirin therapy (n=80).

After 7.8 years, all participants were offered intensified therapy, and the researchers continued to follow-up for an additional 13.4 years.

During follow-up, 10 participants in the intensive therapy group were hospitalized for heart failure compared with 24 in the conventional therapy group. Compared with the conventional therapy group, the intensive group had a hazard ratio of 0.30 (95% CI, 0.14-0.64; P =.002).

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Oellgaard J, Gæde P, Rossing P, et al. Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study [published online May 30, 2018]. Diabetologia. doi: 10.1007/s00125-018-4642-y