The tablet formulation of levothyroxine requires gastric pH in order to dissolve and be appropriately absorbed by the intestine. Interference from other treatments such as proton-pump inhibitors, however, may prevent proper absorption.

Recently, new levothyroxine formulations have been developed, some of which are now available in some countries. One such new formulation is a liquid oral solution that does not require dissolution for absorption.

To determine whether the liquid oral solution prevents the malabsorption caused by proton-pump inhibitors, researchers evaluated outcomes in patients before or after switching from the tablet to liquid formulation.

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Their results provide insight into the potential of novel levothyroxine formulations in improving patient outcomes.

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