Low Incidence of ESRD Reported in Childhood-Onset Type 1 Diabetes

HealthDay News — Among patients with childhood-onset type 1 diabetes, there is a very low incidence of end-stage renal disease (ESRD), according to a Norwegian study published online in Diabetes Care.

Vibeke Gagnum, MD, PhD student, from Oslo University Hospital in Norway, and colleagues estimated the cumulative incidence of ESRD by linking the Norwegian Childhood Diabetes Registry to the Norwegian Renal Registry. Patients (7871) were diagnosed during the periods 1973 to 1982 and 1989 to 2012 and followed through Nov. 30, 2015.

The researchers found that the mean time from diabetes diagnosis to the development of ESRD was 25.9 years. The cumulative incidence of ESRD was 0.7% at 20 years of diabetes duration, 2.9% at 30 years of duration, and 5.3% at 40 years of duration.

Women had lower risk of developing ESRD compared to men (hazard ratio [HR] 0.61), while ESRD risk was higher in individuals in whom diabetes had been diagnosed at 10 to 14 years of age versus those in whom it was diagnosed before 10 years of age (HR 1.29).

“We report a very low incidence of ESRD among patients with childhood-onset diabetes in Norway,” the authors write.

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Gagnum V, Saeed M, Stene LC, Leivestad T, Joner G, Skrivarhaug T. Low incidence of end-stage renal disease in childhood-onset type 1 diabetes followed for up to 42 years [published online October 12, 2017]. Diabetes Care. doi: 10.2337/dc17-0906