HealthDay News — For vitamin D-deficient overweight and obese children, high-dose supplementation with vitamin D does not improve measures of arterial endothelial function or stiffness, but it does result in reductions in blood pressure (BP) and fasting glucose concentration, according to a study published online Jan. 17 in The American Journal of Clinical Nutrition.

Kumaravel Rajakumar, M.D., from the University of Pittsburgh School of Medicine, and colleagues examined whether supplementation with vitamin D3 1,000 or 2,000 IU/day is more effective than 600 IU/day for improving arterial endothelial function, arterial stiffness, central and systemic BP, insulin sensitivity, fasting glucose concentration, and lipid profile in 225 vitamin D-deficient overweight and obese children (aged 10 to 18 years).

The researchers observed no difference between children receiving 1,000 or 2,000 IU/day and those receiving 600 IU/day in the changes at three and six months in endothelial function, arterial stiffness, systemic-systolic BP, lipids, and inflammatory markers. There were some between-group differences noted in secondary outcomes. At six months, central-systolic, central-diastolic, and systemic-diastolic BP were lower in the 1,000-IU versus the 600-IU group (−2.66, −3.57, and −3.28 mm Hg, respectively). In the 2,000-IU group, insulin sensitivity increased at three and six months and fasting glucose concentration decreased at six months (−2.67 mg/dL).

“Vitamin D status optimization, through its beneficial effects on BP and glucose homeostasis, may have a primary preventive role in improving the long-term cardiovascular health of overweight and obese children,” the authors write.


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One author disclosed financial ties to Quest Diagnostics.

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