Disrupting Deep Sleep Doesn’t Affect Luteinizing Hormone Secretion in Puberty

In pubertal children, disrupting deep sleep does not affect luteinizing hormones.
In pubertal children, disrupting deep sleep does not affect luteinizing hormones.
In pubertal children, disrupting deep sleep does not affect luteinizing hormone secretion.

Results: An average of 68.1 ±10.7 (± SE) auditory stimuli were delivered to interrupt deep sleep during the disruption night, limiting deep sleep to only brief episodes (average length disrupted 1.3±0.2 min vs normal 7.1±0.8 min, p<0.001), and increasing the number of transitions between NREM, REM, and wake (disrupted 274.5±33.4 vs. normal 131.2±8.1, p=0.001). There were no differences in mean LH (normal: 3.2±0.4 vs. disrupted: 3.2±0.5 IU/L), LH pulse frequency (0.6±0.06 vs. 0.6±0.07 pulses/hr), or LH pulse amplitude (2.8±0.4 vs 2.8±0.4 IU/L) between the two nights. Poisson process modeling demonstrated that the accumulation of deep sleep in the 20 min before an LH pulse, whether consolidated or fragmented, was a significant predictor of LH pulse onset (p<0.001).

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