Weight Loss Not Increased With Nutrigenetic-Based Diet

(HealthDay News) — A nutrigenetic-based diet does not increase weight loss, compared with a standard balanced diet, according to a study published in Clinical Gastroenterology and Hepatology.

Karen A. Frankwich, MD, from the University of California, San Diego, and colleagues prospectively studied 51 obese or overweight U.S. veterans on an established weight management program (the MOVE! program). Participants were randomly assigned to a nutrigenetic-guided diet (balanced, low-carbohydrate, low-fat, or Mediterranean; 30 patients; based on results from the Pathway FIT test) or a standard balanced diet (21 patients).

The researchers observed no significant difference between the groups in the percentage of participants who lost 5% of their body weight at 8 weeks (35.% on the balanced diet and 26.9% on the nutrigenetic-guided diet). 

Adherence to the diets was challenging in both groups. However, for the nutrigenetic-guided diet, adherence correlated with weight loss; this was not the case for the standard therapy group. 

At 8 weeks, the most weight was lost by participants who had low-risk polymorphisms for obesity (5.0% vs. 2.9% among all other participants; P=.02). They also had significantly greater reductions in BMI (6.4% vs. 3.6%; P=.03) and waist circumference (6.5% vs. 2.6%; P=.02) at 24 weeks.

“Genetic features can identify individuals most likely to benefit from a balanced diet weight loss strategy,” the researchers wrote.

Several authors disclosed financial ties to Pathway Genomics, which funded the study.


  1. Frankwich KA, Egnatios J, Kenyon ML, et al. Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2015;13(9):1625-1632.