Roux-en-Y Gastric Bypass Improved Metabolic Profile

(HealthDay News) — Roux-en-Y gastric bypass (RYGB) is associated with attenuated markers of oxidative stress in subcutaneous adipose tissue, according to a study published recently in Diabetes.

X. Julia Xu, PhD, from the Boston University School of Medicine, and colleagues examined how AMP-activated protein kinase (AMPK) activity, oxidative stress, inflammation and insulin resistance are affected by RYGB surgery. 

They studied 11 patients immediately before and 3 months after surgery.

AMPK activity increased 3.5-fold after surgery, and oxidative stress decreased by 50% in subcutaneous adipose tissue, the researchers found. There was also an 80% reduction in malonyl-CoA levels. 

There were improvements in both BMI and insulin sensitivity, and an increase in circulating high molecular weight (HMW) adiponectin, while fasting plasma insulin levels decreased. 

The expression of inflammatory markers was unchanged postoperatively in subcutaneous adipose tissue, although there was a 50% decrease in plasma C-reactive protein.

“We demonstrated that three months postoperatively, there is a substantial improvement in the patients’ metabolic profile as assessed by changes in body weight, BMI, circulating HMW adiponectin, insulin sensitivity, and increased adipose tissue AMPK phosphorylation/activation,” the researchers wrote.


  1. Xu XJ et al. Diabetes. 2015;doi:10.2337/db14-1765.