Obesity, Metabolic Syndrome May Increase Prostate Cancer Recurrence

HealthDay News — Obesity and metabolic syndrome are associated with increased recurrence among men with prostate cancer who undergo radical prostatectomy (RP), according to a study presented at the American Association for Cancer Research Special Conference — Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes — held from January 27 to 30 in Austin, Texas.

Arash Samiei, MD, from the Allegheny Health Network in Pittsburgh, and colleagues examined the correlation of body mass index (BMI) and metabolic syndrome with oncologic outcome in a retrospective study of 1100 prostatectomies, with a median follow-up of 44 months.

The researchers found that there were more obese patients in the high- vs low-/intermediate-risk group (41.2% vs 32.0%; P =.006). In each of the risk groups there was no statistically significant difference between surgical margin status.

Higher Gleason score was seen in association with metabolic syndrome (P <.001) and a BMI >30 kg/m² (P =.028). Significantly higher biochemical recurrence was seen for patients with BMI >30 vs <30 kg/m² (32.4% vs 16.9%; P <.001). Compared to patients without metabolic syndrome, those with metabolic syndrome had increased risk of biochemical recurrence (odds ratio, 4.06; P <.001).

“Our study indicates that prostate cancer patients who are obese or have metabolic syndrome undergoing RP may have a higher chance for recurrence of the disease, and these individuals should have more focused follow-up care,” Samiei said in a statement.

Reference

Obese men may have higher chance of recurrence following radical prostatectomy [news release]. Austin,TX; American Association for Cancer Research: January 26, 2018. Accessed January 29, 2018.