(HealthDay News) — Overweight and obesity are associated with increased risk for development of chronic kidney disease, even in patients who are metabolically healthy, according to research published in the Annals of Internal Medicine.

Yoosoo Chang, MD, PhD, of Sungkyunkwan University in Seoul, South Korea, and colleagues conducted a prospective cohort study of 62 249 young and middle-aged, metabolically healthy, men and women who did not have chronic kidney disease or proteinuria at baseline. The risk for incident chronic kidney disease across categories of body mass index was assessed.

The researchers found 906 cases of incident chronic kidney disease during 369 088 person-years of follow-up. Compared with normal-weight participants, the multivariable adjusted differences in 5-year cumulative incidence of chronic kidney disease, in cases per 1000 persons, were −4.0 (95% CI, −7.8 to −0.3) in underweight, 3.5 (95% CI, 0.9-6.1) in overweight, and 6.7 (95% CI, 3.0-10.4) in obese participants, respectively.

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“These findings show that metabolically healthy obesity is not a harmless condition and that the obese phenotype, regardless of metabolic abnormalities, can adversely affect renal function,” the researchers wrote.


  1. Chang Y, Ryu S, Choi Y, et al. Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study. Ann Intern Med. 2016. doi:10.7326/M15-1323.