Objective:

The present study aimed at examining if intranasal insulin, which is known to transiently increase brain insulin levels in humans, would improve odor-cued reactivation of spatial memory in young men.

Results:

Intranasal insulin improved the delayed (i.e. free) but not immediate odor-cued recall of spatial memory. This effect was independent of odor type and in the absence of systemic side effects (e.g. fasting plasma glucose levels remained unaltered). In contrast, place and odor recognition remained unaffected by the insulin treatment.

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