(HealthDay News) — Vitamin D deficiency is associated with dry eye and impaired tear function, according to a study published in the International Journal of Rheumatic Diseases.
Pelin Yildirim, MD, from the Kocaeli Derince Training and Research Hospital in Turkey, and colleagues evaluated 50 premenopausal women with vitamin D deficiency (serum vitamin D levels <20 ng/mL) and 48 controls for dry eye parameters.
The researchers found that among patients with vitamin D deficiencies, lower scores in Schirmer’s test and tear break-up time test and higher in ocular surface disease index were seen compared with controls (P<.05). Stanford Health Assessment Questionnaire scores showed no significant correlation with dry eye parameters (P>.05).
Vitamin D level was negatively correlated with ocular surface disease index (P<.001) and positively with Schirmer’s test (P=.001) and tear break-up time test scores (P=.029).
“Dry eye and impaired tear function in patients with vitamin D deficiency may indicate a protective role of vitamin D in the development of dry eye, probably by enhancing tear film parameters and reducing ocular surface inflammation,” the researchers wrote.