Vitamin D Deficiency Associated With Dry Eye Syndromes

(HealthDay News) — Patients with vitamin D deficiency should be evaluated for dry eye syndromes, according to a study published in the International Journal of Rheumatic Diseases.

Pelin Yildirim, MD, from the Kocaeli Derince Training and Research Hospital in Turkey, and colleagues assessed the relationship between vitamin D deficiency and dry eye and impaired tear function in 98 premenopausal women (50 with vitamin D deficiency).

The researchers found that patients with vitamin D deficiency had lower scores in Schirmer’s test and tear break-up time test (TBUT) and higher scores in the ocular surface disease index (OSDI). 

Fatigue severity scale was negatively correlated with Schirmer’s test and TBUT scores, while visual analogue scale-pain was negatively correlated with TBUT scores. 

Stanford Health Assessment Questionnaire scores showed no significant correlation with dry eye parameters. 

Vitamin D level was negatively correlated with OSDI and positively with Schirmer’s test and TBUT scores.

“Dry eye and impaired tear function in patients with vitamin D deficiency may indicate a protective role of vitamin D in the development of dry eye, probably by enhancing tear film parameters and reducing ocular surface inflammation,” the researchers wrote.


  1. Yildirim P et al. Int J Rheum Dis. 2015;doi:10.1111/1756-185X.12727.