HealthDay News — Body mass index (BMI) ≥25 kg/m2 is independently associated with increased risk of endometrial cancer among Chinese women presenting with postmenopausal bleeding, according to a study published online June 30 in Menopause.

Fangzhi Liu, M.B.Ch.B., from the Prince of Wales Hospital in Hong Kong, and colleagues examined whether BMI of 25 kg/m2 would delineate increased risk of endometrial cancer in a cohort of 4,164 women referred for postmenopausal bleeding. Participants had a medical history taken and underwent BMI measurement, transvaginal pelvic ultrasonography, and endometrial sampling.

Within the cohort, 20.8 and 38.7 percent were overweight (BMI, 23 to 24.9 kg/m2) and obese (BMI, ≥25 kg/m2), respectively, and 3.9 percent had endometrial cancer. The researchers observed an association for prevalence of endometrial cancer with BMI category. Compared with BMI <25 kg/m2, BMI ≥25 kg/m2 was independently associated with a 1.57-times increased risk of endometrial cancer in multivariable analysis.

Continue Reading

“This study highlights the known relationship between BMI and endometrial cancer and suggests that the Asian BMI standard for obesity (≥25 kg/m²) helps to identify endometrial cancer in Asian women with postmenopausal bleeding,” Stephanie Faubion, M.D., medical director of the North American Menopause Society, said in a statement. “Key takeaways are that all women with postmenopausal bleeding should undergo evaluation, and obesity remains an important and modifiable risk factor for endometrial cancer, with a linear relationship between BMI and endometrial cancer risk.”

Abstract/Full Text (subscription or payment may be required)