(HealthDay News) — Higher vitamin D levels were associated with a negative effect on prognosis in amyotrophic lateral sclerosis (ALS), according to a study published in CNS Neuroscience & Therapeutics.

Hélène Blasco, PharmD, PhD, from the Université François-Rabelais in Tours, France, and colleagues prospectively collected vitamin D serum concentrations from 125 consecutive patients with ALS. Levels were assessed in relation to clinical parameters and survival.

The researchers found that the mean vitamin D concentration was below the study laboratory’s lower limit of normal (P<.0001) and did not change during the course of the disease.

In patients with bulbar onset, the concentrations were higher (P=.003) and were negatively associated with BMI (P=.0095).

Vitamin D concentrations predicted worse prognosis in models with ALS Functional Rating Scale-Revised and BMI as covariates.

“Our study adds to the growing literature on the relationship between neurological disorders and hypovitaminosis D. In this study, there was a negative effect of higher vitamin D levels on the course of ALS, a finding at odds with some previous studies,” the researchers wrote.

“The mechanisms underlying the relationship between vitamin D and ALS are still obscure; well-designed prospective studies are needed to better understand the involvement of vitamin D in ALS.”


  1. Blasco H et al. CNS Neurosci Ther. 2015;doi:10.1111/cns.12423.