(HealthDay News) — In lean adolescents and in obese adolescents with type 2 diabetes, but not obese adolescents with normoglycemia, 25-hydroxyvitamin D (25[OH]D) is inversely associated with some measures of arterial stiffness, according to a study published in Diabetes Care.

Pranati Jha, MBBS, from the Cincinnati Children’s Hospital Medical Center and University of Cincinnati, and colleagues conducted a cross-sectional analysis to examine the correlation between 25(OH)D levels and arterial stiffness in obese youth with and without type 2 diabetes. 

Data were included for 190 youth with type 2 diabetes, 190 obese control participants without type 2 diabetes and 190 lean control participants without type 2 diabetes (mean age, 17.9 years).

The researchers found that for lean individuals, obese individuals, and obese individuals with type 2 diabetes, the mean 25(OH)D levels were 21.27 ng/mL, 14.29 ng/mL and 14.13 ng/mL, respectively (P<.01). 

From lean to obese to type 2 diabetes individuals, pulse wave velocity (PWV), augmentation index (AIx) and brachial distensibility worsened (P<.01). 25(OH)D level correlated independently with PWV in lean individuals and with AIx in the group with type 2 diabetes; a 3 ng/mL increase in 25(OH)D correlated with a 1% decrease in AIx.

“25(OH)D is inversely associated with some measures of arterial stiffness in lean adolescents and obese adolescents with [type 2 diabetes] but not in obese normoglycemic adolescents,” the researchers wrote. “Future studies are needed to determine if supplemental 25(OH)D is important for cardiovascular health.”


  1. Jha P et al. Diabetes Care. 2015;doi:10.2337/dc15-0111.