Urine Metabolomic Profiling: 5-HT Metabolism Contributes to DM Pathogenesis

Obese youth with type 2 diabetes have a distinct metabolomic profile, according to research presented at ENDO 2017: the 99th Annual Meeting & Expo, April 1-4, in Orlando, Florida.

Pinar Gumus Balikcioglu, MD, from the Duke University Medical Center in Durham, North Carolina., and colleagues recruited 33 obese African-American children ages 8 to 18 from pediatric obesity and diabetes clinics. 

Twenty-four hour urine samples were analyzed to identify key urinary metabolic signatures.

The researchers found that among 187 metabolites identified, three metabolites were significantly higher in obese youth with type 2 diabetes than in obese youth without diabetes. The 3 metabolites related to mitochondrial dysfunction and respiratory chain defects. 

Compared to those without diabetes, subjects with diabetes had a significantly lower level of one metabolite, 5-hydroxy-indoleacetic acid, the major metabolite of serotonin (P =.0007).

“Validation of our findings in larger clinical trials could provide a new noninvasive approach to identification of biomarkers for metabolic risk in both children and adults,” Balikcioglu said in a statement. 

“More importantly, analysis of serotonin metabolism may provide new therapeutic targets for diabetes prevention and treatment.”

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Balikcioglu PG, Bain J, Muehlbauer M, O’Connell TL, Chalew SA, Freemark M. Pathogenesis of type 2 diabetes in obese adolescents: metabolites of serotonin and mitochondrial function in 24-hour urine samples. Abstract OR30-1. Presented at: ENDO 2017; April 1-4, 2017; Orlando, FL