HealthDay News — There is considerable variation in adherence across medication classes for the treatment of type 2 diabetes (T2D), according to a review published online in Diabetes, Obesity and Metabolism.
Andrew McGovern, BMBS, from the University of Surrey in Guildford, UK, and colleagues conducted a systematic literature review of observational studies comparing medication adherence or persistence between 2 or more glucose-lowering medications in individuals with T2D. Data were included for 48 studies.
The researchers found that adherence was better for sulfonylureas and thiazolidinediones compared with metformin (mean difference, 10.6% [95% CI, 6.5% to 14.7%] and 11.3% [95% CI, 2.7% to 20.0%], respectively). Compared with sulfonylureas, thiazolidinedione adherence was marginally better (mean difference, 1.5%; 95% CI, 0.1% to 2.9%).
Adherence was better for dipeptidyl peptidase-4 inhibitors than sulfonylureas and thiazolidinediones. Compared with long-acting analogue insulins, glucagon-like peptide-1 receptor agonists had a higher odds ratio for discontinuation (1.95 [95% CI, 1.17 to 3.27]).
Better persistence was seen for long-acting insulin analogues vs human insulins (mean difference, 43.1 days [95% CI, 22.0 to 64.2 days]). There was considerable variability in the methods for defining adherence and persistence.
“Adherence varies considerably across different medication classes used for the treatment of T2D,” the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
McGovern A, Tippu Z, Hinton W, Munro N, Whyte M, de Lusignan S. Comparison of medication adherence and persistence in type 2 diabetes: a systematic review and meta-analysis [published online November 14, 2017]. Diabetes Obes Metab. doi: 10.1111/dom.13160