Type 2 Diabetes Associated With Some Apolipoproteins

HealthDay News — Apolipoprotein (apo) CIII and apoCIII-to-apoA1 ratio are correlated with incident type 2 diabetes, according to a study published in Diabetes Care.

Adela Brahimaj, MD, from the Erasmus University Medical Center in Rotterdam, Netherlands, and colleagues used data from 971 individuals from the prospective population-based Rotterdam Study to examine the role of apolipoproteins on the risk for type 2 diabetes. They examined the correlation of high-density lipoprotein (HDL) cholesterol cholesterol, apoA1, apoCIII, apoD, and apoE and the ratios of apolipoproteins with apoA1 with type 2 diabetes risk.

The researchers found that during a median follow-up of 13.5 years, 110 individuals developed diabetes. HDL cholesterol, apoCIII, apoE, apoCIII-to-apoA1 ratio, apoE-to-apoA1 ratio, and apolipoproteinic score remained significant after adjustment for age, sex, body mass index, parental history of diabetes, hypertension, alcohol use, smoking, prevalent cardiovascular disease, and serum lipid-reducing agents (per 1 standard deviation naturally log-transformed hazard ratios [HRs]: 0.74, 1.65, 1.36, 1.72, 1.28, and 1.6, respectively). After adjustment for triglycerides in the last model, only apoCIII and apoCIII-to-apoA1 ratio remained significant (HRs: 1.42 and 1.56, respectively).

“Serum apoCIII levels as well as apoCIII-to-apoA1 ratio are associated with incident type 2 diabetes,” the researchers wrote. “They are associated independent of known risk factors and stronger than HDL cholesterol levels.”

Disclosures: One author disclosed financial ties to the nutrition and lifestyle industries.

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  1. Brahimaj A, Ligthart S, Ikram MA, et al. Serum levels of apolipoproteins and incident type 2 diabetes: a prospective cohort study [published online December 29, 2016]. Diabetes Care. doi:10.2337/dc16-1295