HealthDay News – For patients with type 2 diabetes, novel oral glucose lowering drugs are associated with reduced risks of all-cause mortality, cardiovascular disease (CVD), and hypoglycemia, compared with insulin use, according to a study published online in Diabetes, Obesity and Metabolism.

Thomas Nyström, MD, from Karolinska Institutet in Stockholm, and colleagues compared use of novel oral glucose lowering drugs (either dipeptidyl-peptidase-4 inhibitors [DPP-4i] or sodium glucose cotransporter-2 inhibitors) with insulin treatment in a propensity score matched analysis involving 21,758 patients matched in a 1:1 ratio.

The researchers observed reductions in the risk of all-cause mortality, CVD, and hypoglycemia in the novel glucose lowering drug group vs the insulin group (hazard ratios [HRs], 0.56 [95% CI, 0.49-0.64], 0.85 [95% CI, 0.73-0.99], and 0.26 [95% CI, 0.12-0.57], respectively). 

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Dapagliflozin correlated with lower risks of all-cause mortality and CVD (HRs, 0.44 [95% CI, 0.28-0.70] and 0.51 [95% CI, 0.30-0.86], respectively), while DPP-4i correlated with reduced risk of all-cause mortality (HR, 0.59 [95% CI, 0.51-0.67]) but not CVD (HR, 0.87 [95% CI, 0.75-1.01]).

“Dapagliflozin was associated with lower risk of both all-cause mortality and CVD, whereas DPP-4i was only associated with lower risk of all-cause mortality,” the authors wrote.


Several authors disclosed financial ties to the pharmaceutical industry.

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Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson JW. Novel oral glucose lowering drugs compared to insulin are associated with lower risk of all-cause mortality, cardiovascular events and severe hypoglycemia in type 2 diabetes patients [published online January 24, 2017]. Diabetes Obes Metab. doi: 10.1111/dom.12889